SIS3 HCl

Cat. No.: OB0225WX-2721

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: SIS3 acts as a novel and specific inhibitor of Smad3 that suppresses TGF-beta and activin signaling by blocking Smad3 phosphorylation, while remaining inactive against MAPK/p38, ERK, or PI3-kinase pathways.

Synonym: SIS3; 521984-48-5; Sis3 HCl; SIS3 hydrochloride; (E)-SIS3; MFCD09265258; (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride; SIS 3; (E)-1-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenylpyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one;hydrochloride; 2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-, hydrochloride (1:1), (2E)-; Caneritinib; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline Monohydrochloride; SIS 3 Hydrochloride; SIS3(HCl); SIS-3; Specific Inhibitor of Smad3; (2E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride; (E)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one HCl; (E)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)prop-2-en-1-one hydrochloride; isoquinoline, 1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-, monohydrochloride

CAS No.: 521984-48-5

Compound CID: 16079005

Formula: C₂₈H₂₇N₃O₃·HCl

Formula Weight: 489.99

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: SIS3 HCl is employed in fibrotic disease research as a potent and selective inhibitor of Smad3 phosphorylation to investigate the disruption of TGF-beta1-induced myofibroblast differentiation and extracellular matrix production.