Overview of Akkermansia Colonization

Akkermansia is a group of Gram-negative anaerobic bacteria. It is found primarily in the intestinal tracts of animals and humans and is particularly closely associated with the health and disease state of the host. Akkermansia plays a key protective role in the intestinal ecosystem against metabolic diseases such as obesity and diabetes. Our company has extensive experience in Obesity Microbiota Colonization Studies. Through a comprehensive design and a dedicated biological team, Protheragen provides a systematic analysis of Akkermansia abundance changes in metabolic diseases, detailing the molecular mechanisms that explain the specificity of Akkermansia and its derivatives in obesity.

Akkermansia: A Potential Candidate for Ameliorating Metabolic Diseases

Characteristics of Akkermansia

Our company provides isolation and characterization services for Akkermansia. We use genomic fingerprinting (enterobacterial repetitive intergenic consensus polymerase chain reaction (PCR))to characterize isolated strains. Moreover, we use real-time fluorescent quantitative PCR (qPCR) to analyze the fecal microbiota.

Analysis of the Relationship between Akkermansia and Obesity

To investigate the relationship between Akkermansia and obesity further, our company provides a professional Mouse Obesity Model and collects cecum feces for further analysis.

• Basic indicator testing
  • For Akkermansia-transplanted obese mice, we offer various metrics testing services, including, but not limited to, blood analysis, body weight analysis, fat distribution analysis, and feeding analysis.
• Gut flora and metabolomic analysis
  • We use qPCR on fecal analysis to compare the amount of Akkermansia in the obese and normal groups. Changes in Akkermansia abundance in the intestines are presented to the client as a heat map. Our professional data processing team provides visualization data processing services.
  • Our lab provides 16S rRNA sequencing to analyze the association between fecal Akkermansia and obesity.
  • Our researchers provide services for the identification and analysis of intestinal contents by liquid chromatography with tandem mass spectrometry (LC-MS/MS) and the discovery and identification of biomarkers for the onset and progression of obesity.

Workflow

Applications

• Akkermansia is a potential candidate for ameliorating metabolic diseases, and thus our service lays the foundation for the development of anti-obesity therapies.
• Our services can be used to screen compounds such as polyphenols that promote the growth of Akkermansia.
• Akkermansia serves as a potential target for metabolic diseases such as obesity and diabetes, and fights disease at the microbial level.

Advantages of Us

• Whether you want to test the effects of Akkermansia colonization on cells or animal models, our company has a reliable biological team to provide clients with comprehensive transplantation, colonization, and subsequent analysis services.
• Our data analysis team has strong data analysis capabilities to process and interpret large amounts of microbiome data, including macroeconomic, macrotranscriptomics, and metabolomic data.
• Our highly trained research team with extensive research experience in the field of gut microbiome and metabolic diseases validated the role of Akkermansia in obesity and explored its potential as a therapeutic tool through a comprehensive design and analysis.

Learn More about Obesity

Publication Data

Frequently Asked Questions

1. What diseases are Akkermansia strongly associated with?

   Akkermansia, specifically A. muciniphila, as a microorganism found in the human gut, has been strongly implicated in a variety of diseases. Studies have shown that it plays an important role in the development of obesity, type 2 diabetes, metabolic syndrome, cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and some cancers. If you are interested in other mechanisms of disease onset and development, we offer personalized research programs to meet your needs.

2. How does Akkermansia affect metabolism?

   Akkermansia influences human metabolism through a variety of mechanisms, including degradation of intestinal mucus to maintain barrier function, production of short-chain fatty acids to influence energy metabolism and hormone levels, modulation of the inflammatory response to reduce systemic inflammation, and indirectly by altering the structure of the gut microbial community, which together contribute to metabolic homeostasis and weight management.

At Protheragen, we provide high-quality Akkermansia colonization studies, focusing on unraveling the intricate relationship between gut microbiota and obesity. Whether you want to analyze changes in intestinal flora or identify metabolites, please feel free to contact us to explore together.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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