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Genetics Analysis Service of Microbiota in Obesity

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Overview

Gut microbes are usually shaped by their mothers at birth and then further influenced by environmental factors such as host nutrition, lifestyle, immune status, and medication during host growth and development, leading to their alteration. Combining multiple disciplines such as microbiology, genetics, and bioinformatics, Protheragen provides our clients with high-quality personalized genetics analysis of microbiota in obesity.

Crack the Genetic Code Using Our Advanced Sequencing

Relying on a variety of technologies, including next-generation sequencing (NGS), we help clients to deeply analyze the relationship between the gut microbiome and the host genetic background. Based on genome-wide association analysis, we establish the linkage between gut microbiome and host genetics and provide a high-throughput analysis of the relationship between host genetics and the gut microbiome.

  • Analysis Service of Microbiota in Placenta

Based on high-throughput sequencing technology, our company provides microbial composition and abundance analysis services in placental samples. Moreover, our researchers provide professional microbial community structure, function prediction, and analysis of microbial markers associated with obesity.

  • Analysis Service of Microbiota in Amniotic Fluid

Our staff has extensive operational experience in microbial DNA extraction and sequencing of amniotic fluid samples, helping clients to reveal microbial community structure rapidly. We provide an association analysis service between microbiota and fetal development and obesity risk.

  • Analysis Service of Microbiota in Umbilical Cord Blood

We provide high-quality cord blood microbiota analysis services. We extract microbial DNA from umbilical cord blood and perform deep sequencing to identify microbial species and gene expression. Moreover, we provide microbial exposure and obesity susceptibility assessment services for newborns at birth.

  • Analysis Service of Microbiota in Meconium

Our company offers services for analyzing microbial composition and dynamic changes in fetal stool samples. For example, we test the total number of anaerobic bacteria, composition, and distance values of microorganisms. Moreover, we provide fecal colony DNA sample sequencing services.

Workflow

Schematic of microbiota genetics analysis. (Protheragen)

Applications

  • Microbiota genetics analysis can be used to assess the risk of obesity in newborns and provide a basis for early intervention.
  • Microbiota genetics analysis provides data support for scientific programs studying the relationship between obesity and the microbiota.
  • Microbiota genetics analysis can be used to measure host single gene changes with effects on gut microbes.
  • Microbiota genetics analysis can be used for quantitative trait characterization and heritability estimation of gut microorganisms.

Advantages of Us

  • From sample collection to data analysis, our company performs strict quality control at every step to ensure the accuracy and reliability of the results.
  • We have a professional bioinformatics team to analyze the sequencing data and identify microbial species and gene expression patterns.
  • Based on the results of the analysis, we provide a detailed report including microbial community structure, functional predictions, and genetic markers associated with obesity.

Your Trusted Obesity Research Associate

Relying on our rich research experience and a professional biotechnology team, we are committed to providing a full range of obesity research services. We focus on discovering anti-obesity targets and developing anti-obesity therapies to meet the diverse research needs of our clients.

Publication Data

Technology: Genome analysis, Epigenome analysis, Transcriptome analysis

Journal: Current Diabetes Reports

Published: 2019

IF: 5.2

Results: This article evaluates the impact of specific epigenetically mediated mechanisms and microbiota-induced epigenetic modifications on adipose tissue and the development of diseases such as obesity. Differential methylation of genes was found between human subcutaneous adipose tissue and omental visceral adipose tissue in non-obese and obese individuals. Epigenetic modifications are reversible and modifiable and thus may be potential targets for disease treatment that can be intervened with diet, microbiota, or pharmacotherapy.

Fig.1 Schematic diagram of epigenetic modifications.Fig.1 Epigenetic modifications and interventions. (Stols-Gonçalves, et al., 2019)

Frequently Asked Questions

  1. What are the sample requirements for this service?

    Samples need to be collected under sterile conditions and sent to the laboratory for processing as soon as possible.

  2. Are these services safe?

    Yes, all of our services follow strict ethical and safety standards to ensure the safety of samples and client information.

Protheragen is committed to providing a scientific basis for the research and prevention of obesity through advanced microbiota genetic analysis services. Utilizing cutting-edge high-throughput sequencing technology and advanced bioinformatics analysis, our company accurately characterizes the genetic profile of individual microbial communities to reveal microbial markers associated with obesity. To find out more about our services, please feel free to contact us.

Reference

  1. Stols-Gonçalves, D.; et al. Epigenetic markers and microbiota/metabolite-induced epigenetic modifications in the pathogenesis of obesity, metabolic syndrome, type 2 diabetes, and non-alcoholic fatty liver disease. Current Diabetes Reports. 2019, 19: 1-9. (CC BY 4.0)

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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