Apoptosis

Overview

Apoptosis is a genetically controlled, cell-autonomous, orderly process of cell death that involves gene activation, gene expression, and gene regulation. In multicellular organisms, apoptosis plays an important role in the removal of unwanted or abnormal cells, the maintenance of a stable internal environment, and the development of multiple systems. Too much apoptosis leads to atrophy, while not enough apoptosis leads to uncontrolled cell proliferation. Altered apoptosis has been associated with the development of diseases, including viral infections, cancer, neurodegenerative diseases, and autoimmune diseases. Protheragen offers clients a wide range of compounds for mechanistic studies of apoptosis and obesity.

Enriched Apoptosis Boosts Your Anti-Obesity Research

Adipocyte apoptosis plays a role in the onset and development of obesity. For example, adipokines (a variety of active factors secreted mainly by adipocytes) affect the metabolic state of the body by regulating various functions such as insulin secretion, gene expression, and apoptosis in pancreatic β-cells.

Fig.1 Two triggering pathways for apoptosis. (Bertheloot, et al., 2021)

Our company offers a wide range of apoptotic compounds such as apoptosis controllers, apoptosis activators, apoptosis inhibitors, apoptosis modulators, and apoptosis inducers to facilitate our clients' anti-obesity programs. Our high-quality compounds have been praised by many clients.

Our apoptosis products have a wide range of metabolic pathways, targets, and receptors to meet the diverse research needs of our clients. If you don't find a specific target, we are ready to help you!

Publication

Applications

• Apoptosis-related compounds play an important role in the study of the mechanisms of various diseases, such as cancer, metabolic diseases, immune diseases, and neurodegenerative diseases.
• Apoptosis can be used to screen compounds with potential anti-obesity activity using high-throughput screening (HTS) and high-content screening (HCS).
• Apoptosis-related compounds can be used for anti-obesity drug development and efficacy optimization.

Frequently Asked Questions

1. What is the biological function of apoptosis?
   • Removal of useless or redundant cells
   • Removal of cells that no longer serve a purpose
   • Removal of cells that are not developing properly
   • Removing some harmful cells
2. What is the difference between apoptosis and necrosis?

   Apoptosis and necrosis have similar endpoints but very different processes. Necrosis is triggered by strong external factors, leading to disorderly cell death, which is characterized by cell expansion, membrane rupture, content leakage, and insufficient DNA degradation, triggering a significant inflammatory response. Apoptosis, on the other hand, is an orderly process of cellular response to environmental changes, whether physiological or pathological stimuli, prompting orderly changes and cell death, which is distinctly different from the characteristics of necrosis.

   Fig.3 Schematic diagram of apoptosis and necrosis. (Dhuriya &Sharma, 2018)

Protheragen not only provides compounds related to apoptosis but also offers a range of services, including but not limited to apoptosis signaling, apoptosis effector molecules, apoptosis-disease relationship, and screening of apoptosis inhibitors and promoters. Please feel free to contact us.

Apoptosis Products