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Angiogenesis

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Overview

(Source: Bioicons, free)

Angiogenesis is the process of forming new blood vessels from the development of existing capillaries or postcapillary venules. It mainly involves the degradation of the vascular basement membrane during the activation phase, activation, migration, growth, and differentiation of vascular endothelial cells. Angiogenesis is a complex process involving multiple cells and molecules and is controlled by chemical signaling in the body, with growth factors such as vascular endothelial growth factor (VEGF) playing a key regulatory role. The binding of VEGF to other growth factors and receptors activates intracellular signaling to promote the growth of new blood vessels. Protheragen also provides other angiogenesis inhibitors to interfere with blood vessel formation.

Choose Protheragen to Dive Into Anti-Obesity Research Together

Our high-quality obesity compound library is a collection of multiple compounds that are commonly used in obesity-related research. Angiogenesis plays an important role in obesity research. Obesity leads to abnormal angiogenesis, which in turn affects the body's metabolism and health. Therefore, some compounds in the obesity compound library exert anti-obesity effects by affecting angiogenesis.

Specifically, certain compounds in the obesity compound library inhibit or promote the expression or activity of angiogenesis-related factors, thereby modulating the angiogenic process. These compounds affect angiogenesis by influencing steps such as proliferation, migration, and lumen formation of vascular endothelial cells, which in turn have therapeutic effects on obesity and its related diseases.

Our company provides not only individual compound products but also related compound libraries to fulfill our clients' research needs in different fields. The obesity library contains a wide range of compounds that affect angiogenesis, and these compounds have different mechanisms of action and targets.

Fig.1 Loss of ANGPTL4 uncouples visceral adiposity from glucose intolerance partly via the gut microbiota. Fig.1 Effect of angiopoietin-like protein 4 deficiency on visceral adiposity. (Janssen, et al., 2018)

Publication

Technology: Immunometric assay, Gas chromatograph

Journal: Scientific Reports

Published: 2018

IF: 3.8

Results: This paper investigated the relationship between ANGPTL4 and gestational weight gain (GWG) in overweight and obese pregnant women. The researchers found that ANGPTL4 concentrations continued to rise throughout pregnancy, while VEGF and leptin did not show the same trend. In overweight and obese pregnant women, measurements of ANGPTL4 concentrations in early pregnancy may serve as an early predictor of future excessive weight gain. This provides a potential new target for the prevention of excessive weight gain during pregnancy.

Fig.2 Maternal plasma concentrations of (a) ANGPTL4 and (b) linoleic acid (LA, 18:2 n-6) at 15, 24, and 32 weeks of pregnancy. Fig.2 Analysis of ANGPTL4 and linoleic acid concentrations in maternal plasma. (Ortega-Senovilla, et al., 2018)

Applications

Angiogenesis-related compounds can be used to screen for compounds with anti-obesity effects, providing candidate molecules for new drug development.
Angiogenesis-related compounds can be used to study the pathogenesis of obesity and its related diseases, providing a basis for developing more effective treatment programs.
Angiogenesis-related compounds can be used to optimize drug structures to improve drug activity and selectivity and reduce side effects.

Advantages of Us

High purity, high quality, and abundant compounds for your one-stop research needs.
Depending on the client's research area, our specialized researchers provide customized compound libraries for clients.
Our high-quality angiogenesis compounds are validated by sophisticated instrumentation such as nuclear magnetic resonance (NMR), high-performance liquid chromatography (HPLC), and liquid chromatography-mass spectrometry (LC-MS).

Frequently Asked Questions

How do these compounds affect the process of angiogenesis?
- Inhibition of the VEGF signaling pathway
- Regulation of angiogenesis-related kinase activity
- Influence on the expression of angiogenesis-related genes
How do I customize my compound library?

Special compound

Quantities

96-well plate

Form

Protheragen provides a wide range of angiogenesis compounds to help our clients in their research on metabolic diseases, such as anti-obesity. If you are interested in our products, please feel free to contact us!

References

Ortega-Senovilla, H.; et al. Angiopoietin-like protein 4 (ANGPTL4) is related to gestational weight gain in pregnant women with obesity. Scientific Reports. 2018, 8(1): 12428. (CC BY 4.0)
Janssen, A.W.; et al. Loss of angiopoietin-like 4 (ANGPTL4) in mice with diet-induced obesity uncouples visceral obesity from glucose intolerance partly via the gut microbiota. Diabetologia. 2018, 61: 1447-1458. (CC BY 4.0)

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