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Sorafenib tosylate
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Cat. No.:
OB0125LY-073
Size:
50 mg; 100 mg; 200 mg; 500 mg; 1 g
CAS No.:
475207-59-1
Compound CID:
406563
Specification
Description:
Sorafenib tosylate is a potent multikinase inhibitor that inhibits multiple tyrosine kinases, including RAF kinase, VEGFR (vascular endothelial growth factor receptor) and PDGFR (platelet-derived growth factor receptor).
Formula Weight:
637.03
Stability:
3 years in powder form.
Applications:
Sorafenib tosylate can be used to inhibit tumor cell proliferation and neoangiogenesis.
Storage:
Storage at -20°C.
Formula:
C21H16ClF3N4O3·C7H8O3S
Appearance:
Solid
Purity:
99.8%
Identity:
Confirmed by HPLC.
Targets&IC50:
PDGFRβ: 57 nM (cell free); c-Kit: 68 nM (cell free); B-Raf V599E: 38 nM (cell free); Raf-1: 6 nM (cell free0; B-Raf: 22 nM (cell free); VEGFR3: 20 nM (cell free)
Relative Density:
1.454 g/cm3
Library Information
Plate Number:
AOCL-7
Plate Location:
d5
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Angiogenesis; Apoptosis; Autophagy; MAPK; Tyrosine kinase/adaptors
Targets:
c-Kit; Autophagy; PDGFR; Apoptosis; VEGFR; FLT; Raf; Ferroptosis
Receptors:
Apoptosis; Autophagy; B-Raf; B-Raf (V599E); c-Kit; Ferroptosis; FLT3; mPDGFRβ; PDGFRβ; Raf; Raf-1; VEGFR; VEGFR2/Flk1
DMSO Max Solubility (mg/mL):
200 mg/mL
DMSO Max Solubility (mM):
313.96 mM
Water Max Solubility (mg/mL):
1 mg/mL
Ethanol Max Solubility (mg/mL):
1 mg/mL
Saline Max Solubility (mg/mL):
5 mg/mL
Saline Max Solubility (mM):
7.85 mM
ALogP:
5.824
HBA_Count:
4
HBD_Count:
3
Rotatable Bond:
7