Individual Genetic Profiling Service for Obesity Risk Prediction
InquiryEmpower Your Health Journey with Personalized Genetic Insights
Protheragen offers a state-of-the-art individual genetic profiling service designed to predict obesity risk by analyzing a person's unique genetic makeup. Our service leverages advanced genome-wide association studies (GWAS) and polygenic risk scores (PRS) to identify key genetic variants linked to obesity and related traits, such as BMI, body fat percentage, and waist-to-hip ratio. By assessing thousands of single-nucleotide polymorphisms (SNPs) across multiple genes, we provide detailed insights into an individual's genetic predisposition to obesity. This genetic information is combined with other personal factors to deliver highly tailored lifestyle recommendations aimed at reducing obesity risk.
Workflow
Through the use of advanced bioinformatics and computational tools, the genetic data is thoroughly analyzed and interpreted, allowing for the integration of clinical and lifestyle factors. This comprehensive approach enables the prediction of overall obesity risk, leading to personalized recommendations designed to help individuals adopt preventive strategies and manage their weight effectively. The following steps outline the process of this service.
Data Collection
DNA samples are collected, typically through non-invasive methods such as saliva or blood, and prepared for genomic analysis.
Genetic Profiling
Genetic profiling is performed using GWAS to analyze thousands of SNPs known to influence obesity. This process identifies key genetic variants linked to obesity risk.
PRS
A personalized PRS is calculated to quantify an individual's genetic predisposition to obesity. This score reflects the cumulative effect of multiple genetic markers.
Analysis and Interpretation
The genetic data is analyzed using advanced computational tools, providing a comprehensive obesity risk profile.
Risk Prediction
The results from genetic profiling are integrated with clinical and lifestyle factors to assess an individual's overall risk of obesity.
Personalized Recommendations
Based on the individual's genetic risk, Protheragen offers personalized lifestyle and intervention strategies, including dietary adjustments, exercise plans, and other preventive measures tailored to reduce obesity risk.
Applications
- By understanding an individual's genetic predisposition to obesity, Protheragen's service helps to create personalized diet and exercise plans aimed at mitigating the risk of weight gain and associated health conditions, such as diabetes or heart disease.
- Early identification of individuals with a high genetic risk for obesity enables proactive intervention before the onset of obesity or related complications. This allows for preventive measures to be implemented, potentially reducing the future burden of obesity-related health issues.
- Researchers can use this service to investigate the relationship between genetic predisposition and environmental influences on obesity. It can also help develop new treatments or interventions.
Advantages
- One of the greatest strengths of Protheragen's genetic profiling service lies in its ability to offer personalized health insights. By identifying genetic variations unique to each individual, the service allows for tailored lifestyle interventions that go far beyond general weight management advice.
- Utilizing cutting-edge GWAS technology, the service examines thousands of genetic markers to identify potential risk factors that may contribute to obesity. Generating a PRS provides a comprehensive risk assessment, which quantifies the likelihood of an individual developing obesity based on the combined effects of multiple genetic variants.
- In addition to identifying obesity-related genes, the service also evaluates how these genetic factors interplay with traits like BMI, body fat distribution, and metabolic rates. By integrating this genetic information with other individual factors, such as age, gender, and lifestyle, Protheragen provides a holistic view of one's health, making it easier to understand the root causes of obesity and how to mitigate them effectively.
- Our service is designed not only to predict risk but also to suggest actionable solutions. Personalized interventions based on genetic data can significantly enhance the effectiveness of weight management strategies.
Individual Genetic Profiling Service Used for Therapy Development
Individual genetic profiling provides critical information that can inform targeted therapy development, allowing for more precise and personalized treatments for obesity.
Anti-Obesity Small Molecule Drug Development
- Computer-aided Anti-obesity Drug Discovery Service
Genetic profiling helps identify specific genes associated with obesity. - Anti-obesity Drug Virtual Screening Service
Individual genetic profiles enable virtual screening to prioritize compounds that best match genetic markers associated with obesity.
Gene-Environment Interactions Analysis Service Used for Preclinical Studies
Individual genetic profiling is critical in preclinical stages, especially for developing accurate models and assessments that align with genetic predispositions to obesity.
Publication Data
Technology: GWAS, Quantitative polymerase chain reaction (qPCR), Bioinformatics and statistical analysis, Mendelian randomization
Journal: Frontiers in Nutrition
IF: 4
Published: 2023
Results: This study investigates the genetic factors influencing obesity and weight loss outcomes by analyzing the correlation between 102 single SNPs and BMI in a diverse population. The researchers identified several SNPs, such as FTO, MCM6, HLA, and MC4R, that were significantly associated with increased BMI. Furthermore, SNPs like PPAR-delta and ACSL5 were linked to weight loss across various treatments, including dietary interventions and bariatric procedures. The findings emphasize the importance of personalized treatment plans based on genetic profiling to optimize weight management strategies and improve health outcomes. Nutrigenomics, which combines genetics and nutrition, is highlighted as a promising approach to creating personalized dietary recommendations for weight loss.
Fig.1 Manhattan plot summarizing the statistic results for all SNPs studied under all models of association to the BMI as phenotype. (Mera-Charria, et al., 2023)
Frequently Asked Questions
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What is individual genetic profiling for obesity risk prediction?
This service analyzes a person's genetic makeup to determine their predisposition to obesity. Examining specific genetic variants through GWAS provides a personalized risk score and recommendations for managing or preventing obesity.
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How accurate is the obesity risk prediction?
The prediction is based on a PRS, which calculates an individual's overall genetic predisposition by analyzing multiple genetic markers. While no prediction can be 100% accurate, the integration of genetic and lifestyle data increases the precision of the risk assessment.
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Can this service help people who are already obese?
Yes, the service can provide valuable insights into genetic factors that may be contributing to existing obesity. The personalized recommendations can help individuals manage their weight more effectively and prevent further complications.
At Protheragen, our genetic profiling service for obesity risk prediction harnesses the latest genomic technologies, including GWAS and PRS calculations, to deliver a comprehensive assessment of an individual's genetic predisposition to obesity. Please feel free to contact us for more information if you are interested in our service and our anti-obesity solutions.
Reference
- Mera-Charria, A.; et al. Genetic variant panel allows predicting both obesity risk, and efficacy of procedures and diet in weight loss. Frontiers in Nutrition. 2023, 10: 1274662. (CC BY 4.0)
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.