Epigenome-wide Association Studies (EWAS)-based Obesity-Related Epigenetic Modification Analysis Service
InquiryUnlocking the Secrets of Epigenetics: Transforming Obesity Research at Protheragen
The epigenome-wide association studies (EWAS)-based obesity-related epigenetic modification analysis focuses on identifying epigenetic changes, such as DNA methylation, that influence obesity and related metabolic disorders. By studying these modifications across the genome, key markers such as MSI2, ABCG1, and CPT1A are identified, which play significant roles in BMI regulation and lipid metabolism.
At Protheragen, our EWAS-based analysis service offers comprehensive epigenetic profiling, helping to pinpoint these Crucial Markers and integrate them into the development of personalized anti-obesity therapies. By leveraging cutting-edge technologies and preclinical testing, Protheragen aims to discover therapeutic targets and treatments that address the root epigenetic causes of obesity.
EWAS identifies obesity-related epigenetic markers, such as methylated CpG sites, that directly inform the targeting:
EWAS findings inform model selection and customization, such as gene editing-based models (single or multi-gene mutations) and high-fat or high-sugar-induced obesity models.
- 3T3-L1 preadipocytes, primary human adipocytes, and brown/white fat cells for obesity research.
- Liver Cells (Hepatocytes) to explore liver-specific obesity mechanisms.
The EWAS-based obesity-related epigenetic modification analysis is a comprehensive approach designed to uncover the intricate relationship between epigenetic changes and obesity. This analysis leverages advanced technologies and statistical methods to identify key DNA methylation patterns that may influence metabolic health and obesity progression. At Protheragen, we implement a structured process to facilitate this analysis, enabling us to provide valuable insights and potential therapeutic targets for the development of innovative anti-obesity interventions.
Applications
- Protheragen's EWAS service enables the identification of specific DNA methylation markers associated with obesity.
- By analyzing epigenetic modifications, Protheragen helps tailor anti-obesity interventions based on an individual's unique genetic and epigenetic profile, leading to more effective and personalized treatment strategies.
- The service provides valuable insights into the biological pathways affected by obesity-related epigenetic changes, helping researchers understand the mechanisms through which environmental factors influence weight gain and metabolic health.
- The findings from EWAS can guide the design of various trials by identifying potential biomarkers for monitoring treatment efficacy and response in obesity therapies.
Advantages
- Utilizing cutting-edge technologies, Protheragen processes and analyzes large datasets efficiently, allowing for comprehensive epigenetic profiling within a short time frame.
- Protheragen's team of experts brings extensive experience in epigenetics and obesity research, ensuring high-quality analysis and interpretation of data.
- By focusing on epigenetic modifications, Protheragen offers a cost-effective approach to obesity research, minimizing the need for more expensive genetic sequencing methods while still providing valuable insights.
- Protheragen's analysis helps identify relevant biological pathways affected by obesity-related epigenetic changes, guiding future research and therapeutic development.
Our Services
To support the EWAS-based obesity-related epigenetic modification analysis service, a series of related services enhances comprehensive analysis and the identification of crucial markers. These services provide multi-omics data integration, functional annotation, and gene-environment interaction analysis, which help uncover obesity-related genes and pathways. For more comprehensive service, please click "Our Service".
DNA Methylation Analysis Service
Obesity Epigenomic Service
- Obesity Gene Screening Service
- Anti-obesity or Leanness Gene Screening Service
Publication Data
Technology: Illumina Infinium MethylationEPIC BeadChips, ChIP-seq, Hi-C Interaction, Functional enrichment analysis
Journal: Clinical Epigenetics
IF: 4.8
Published: 2024
Results: This study investigates epigenome-wide DNA methylation and its association with body mass index (BMI) changes in East Asians through longitudinal analysis. The researchers identified three novel CpG sites (cg14671384, cg25540824, and cg10848724) that significantly correlated with BMI changes, with two located in genes previously linked to body shape and metabolic rate. These findings suggest an active regulatory role of DNA methylation in genes associated with energy metabolism and obesity-related traits. Moreover, functional enrichment analysis revealed a strong connection between obesity and type 2 diabetes, emphasizing the potential regulatory pathways from the genome to BMI changes.
Fig.1 Regulatory activity of cg14671384. (Li, et al., 2024)
Frequently Asked Questions
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What is EWAS, and how is it connected to obesity?
EWAS investigates how epigenetic changes, like DNA methylation, are linked to obesity. By detecting unique methylation patterns tied to obesity, EWAS helps uncover the biological processes that drive weight gain and impact metabolic function.
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What types of samples are suitable for EWAS analysis?
Suitable samples for EWAS include biological specimens such as blood, adipose tissue, or other relevant tissues that reflect the epigenetic status associated with obesity. The quality and quantity of the sample are important for accurate analysis.
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What are the potential applications of EWAS findings?
Findings from EWAS can be applied to identify novel biomarkers for obesity, develop personalized treatment strategies, guide trial designs, and enhance our understanding of the environmental impacts on obesity-related epigenetic modifications.
At Protheragen, our EWAS-based obesity-related epigenetic modification analysis service offers a powerful tool for understanding the complex interplay between epigenetic factors and obesity. By leveraging advanced technologies to profile DNA methylation across the genome, we help researchers identify key epigenetic markers that influence metabolic health and susceptibility to obesity. For more information, please feel free to contact us and explore more information from us!
Reference
- Li, W.; et al. Longitudinal analysis of epigenome-wide DNA methylation reveals novel loci associated with BMI change in East Asians. Clinical Epigenetics. 2024, 16(1): 70. (CC BY 4.0)
All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.