Obesity-related Natural Products

Exploring Natural Potency: Natural Compounds in Obesity Research

Protheragen offers a carefully screened and highly purified line of obesity-related natural products designed to provide superior solutions for your obesity research. We understand that obesity is a complex, multifactorial disease that requires a multifaceted research approach. Therefore, our portfolio covers a wide range of natural products that have been shown in the scientific literature to have potential anti-obesity activity or applications in probing obesity mechanisms.

Natural products of plant origin have been shown to exert their anti-obesity effects through a variety of pathways, including stimulation of metabolism and thermogenesis, amylase inhibition, pancreatic lipase inhibition, appetite regulation, and adipogenesis inhibition. With this in mind, our obesity-related natural products cover several key research areas related to obesity, including:

• Natural products that influence adipogenesis and lipolysis
• Natural products that regulate energy metabolism, such as influencing glucose metabolism, improving insulin sensitivity, regulating blood glucose levels, improving mitochondrial function, increasing energy expenditure, etc.
• Natural products with anti-inflammatory effects, e.g., reducing obesity-related inflammation, modulating the release of regulatory cytokines, etc.
• Natural products affecting the gut microbiota, e.g., regulating the composition of gut flora
• Natural products with antioxidant activity, e.g., antioxidants, reducing oxidative stress, etc.

Fig.1 Role of natural plants in reducing appetite and/or inducing satiety. (Shaik Mohamed Sayed, et al., 2023)

Applications

• Prevention strategies: Obesity is a global health problem. Natural products are seen as potential avenues for exploring new, gentler ways of preventing obesity due to their wide range of sources, long history of use, and generally recognized safety profile.
• Development of multi-targeted therapeutics: Many natural products have favorable bioactivity and may act on obesity-related physiological processes through different mechanisms, such as appetite suppression, reduction of fat absorption, promotion of lipolysis, and improvement of metabolism. Co-treating natural products and investigating their therapeutic efficacy provides an effective strategy for exploring combinatorial anti-obesity therapies.
• Exploration of new molecular entities: Natural products are an important source for the discovery of novel anti-obesity drug molecules. By studying the active ingredients of natural products, scientists identify new molecules with potential anti-obesity activity and further develop and optimize them.

Advantages

• Supported by scientific evidence: Our natural products cover natural compounds that have demonstrated in vitro and in vivo studies to have potential effects on key obesity-related pathways such as adipogenesis, energy metabolism, and inflammation.
• High purity and quality assurance: We strictly control the production and quality of our obesity-related natural products to ensure high purity and consistency from batch to batch. Ensuring accuracy and reproducibility is fundamental to generating dependable experimental results.
• Flexible packaging and customization: We offer a wide range of product packaging specifications to meet the needs of experiments of different sizes.

Publication

Frequently Asked Questions

1. What are some common examples of natural products associated with obesity?

   Natural products associated with obesity include terpenes, plant extracts, and more, for example:

   • Green tea extract
   • Caffeine
   • Ephedrine
   • Anthocyanins
   • Capsaicin
   • Free fatty acids
   • Monoglycerols
   • Other plant extracts
2. How do researchers study the mechanism of action of natural products on obesity?
   • In vitro studies: To study the effects of natural products on different types of cells at the cellular level, e.g., to observe their effects on processes such as lipogenesis, metabolism, and absorption.
   • Animal model studies: To simulate obesity using various animal models (e.g., mice, rats, etc.) and assess the anti-obesity effects of natural products in vivo, including weight loss, fat loss, and improvement of metabolic indicators.
   • Metabolomics and intestinal microbiome research: Combine various histological techniques to study the effects of natural products on metabolite profiles and intestinal microbiota, in order to gain a more comprehensive understanding of their anti-obesity mechanisms.
   • Structure-activity relationship studies: Explore which structural features of natural products are related to their anti-obesity activities, and provide guidance for the development of more effective derivatives or analogs.

Protheragen understands the importance of obesity research and is committed to providing researchers around the world with high-quality natural products to advance the field. Whether you are conducting basic research, drug screening, or developing new interventions, we are your trusted partner. Please feel free to contact us for more details about obesity-related natural products.

Natural Products: