- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
JAK/STAT-Targeted Compounds
InquiryOverview
The JAK-STAT pathway is an intracellular signaling mechanism that involves receptor activation, signal transduction, and regulation of gene expression by a series of cytokines. When a cytokine binds to its specific receptor, it triggers the activation of receptor-associated JAK kinase, which phosphorylates the receptor and recruits STAT transcription factors. Phosphorylated STAT transcription factors form dimers and translocate to the nucleus to regulate the expression of specific genes. This pathway plays a key role in immune regulation, cell proliferation, differentiation, and apoptosis.
Protheragen provides a series of compound products targeting the JAK-STAT pathway. These products have been rigorously screened and optimized and are designed to provide you with powerful tools to support your obesity research and to help you gain a deeper understanding of the mechanism of the JAK-STAT pathway's role in obesity occurrence and development.
Fig.1 Typical activation and negative regulation of the JAK-STAT signaling pathway. (Xue, et al., 2023)
JAK/STAT Signaling Pathway
Association of the JAK-STAT Pathway with Obesity
JAK-STAT affects energy homeostasis and weight control in individuals by regulating adipocyte differentiation, proliferation, and metabolic activities. Moreover, the JAK-STAT pathway is involved in regulating energy metabolic processes in the body. For example, leptin, a hormone secreted by adipose tissue, regulates appetite and energy expenditure by activating the JAK-STAT pathway. Our products include highly selective inhibitors, agonists, antagonists, etc., targeting the JAK family (e.g., JAK1, JAK2, JAK3) and STAT family (e.g., STAT1, STAT3, STAT5, etc.).
Fig.2 The JAK-STAT signaling pathway and immune system. (Xue, et al., 2023)
Enriched Pathways
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Diverse Targets
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Applications
- Obesity and Metabolism Research: Our products can be used to study the role of the JAK-STAT signaling pathway in adipocytes, reveal its regulatory mechanism in obesity and metabolic disorders, and provide a theoretical basis for the development of new anti-obesity drugs.
- Immune and Inflammation Research: The JAK-STAT pathway plays an important role in inflammation and immune response, and our products can be used to study its role in obesity-related inflammation.
- Cell Signaling Research: Our products can be used to study the cross-talk between the JAK-STAT pathway and other signaling pathways, revealing the complex network of cell signaling.
Advantages of Us
Superior Performance
Our products offer high sensitivity, high specificity, and broad applicability, significantly improving research efficiency and accuracy.
Product Diversity
From basic molecular biology experiments to complex metabolic studies, our products can meet different research needs and help clients explore the molecular mechanisms of obesity in depth.
Customization Services
We offer customized services to design and synthesize compounds with specific structures to meet individual research needs according to client requirements.
Publication
Title: Leptin-induced JAK/STAT signaling and cancer growth
Journal: Vaccines, 2016
DOI: https://doi.org/10.3390/vaccines4030026
Summary: This literature summarizes the role of the leptin-induced JAK/STAT signaling pathway in cancer growth and its association with obesity. There is a complex relationship between obesity and cancer, in which the JAK/STAT pathway is affected by obesity-related changes, which in turn regulate cancer growth and progression. Leptin promotes cancer growth through multiple mechanisms, including interactions with Notch and IL-1, as well as synergistic effects with other pro-angiogenic factors. The JAK/STAT pathway is regulated by a variety of factors, including cross-talk of other signaling pathways and the inflammatory state of adipose tissue.
Fig.3 The JAK-STAT signalling pathway. (Mullen & Gonzalez-Perez, 2016)
Customer Review
Precision in Signaling Dissection
"We utilized Protheragen's JAK/STAT compound library to precisely study the relevant signaling pathways. This library offers diverse, selective inhibitors, enabling us to meticulously investigate the unique roles of biomolecules in insulin resistance and inflammation."— Prof. C* Y***
Targeted Drug Screening Edge
"Protheragen's JAK/STAT library provides a rich collection of kinase modulators with known pharmacological activity, facilitating our high-throughput screening and identification of several structures. This efficient tool and precise molecular structural information offer significant advantages for our drug development efforts."— C. L* P***
Frequently Asked Questions
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What is the purity of your JAK-STAT pathway compound products?
All of our compound products undergo strict quality control with purity ranging from 95% to 99.99% to ensure the accuracy and reliability of experimental results.
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What diseases are associated with polymorphisms and mutations in JAK-STAT?
Mutations and gene polymorphisms in the JAK-STAT pathway play a broad and important role in the pathogenesis of human diseases. Among them, the most common disease-causing mutation sites are within the SH2 structural domain.
Fig.4 Schematic illustration of the mutation-disease association of the JAK-STAT pathway. (Xue, et al., 2023) -
Can I use this compound library for high-throughput screening platforms?
Absolutely. Our JAK/STAT compound library is specifically optimized for automated high-throughput screening. All compounds have undergone rigorous validation. We offer formats compatible with mainstream 384-well or 96-well plates to maximize your screening efficiency.
The JAK-STAT related product series provided by Protheragen provides powerful tools and solutions for obesity research, helping researchers to deeply understand the molecular mechanism of obesity and promote scientific research and drug development in related fields. Please feel free to contact us.
References
JAK/STAT-Targeted Compounds
- CAS No.: 425399-05-9
- Pathways: JAK/STAT signaling; Cell cycle/Checkpoint; MAPK; GPCR/G protein; Stem cells
- Targets: GTPase superfamily; CDK family
- Receptors: GTPase Cdc42; Ras; STAT3
- CAS No.: 50679-08-8
- Pathways: JAK/STAT signaling; GPCR/G protein; Angiogenesis; Neuronal signaling; Apoptosis; Membrane transporter/Ion channel; Immunology/Inflammation; Tyrosine kinase/adaptors; Proteases/Proteasome
- Targets: Ion channels & transporters; G protein-coupled receptors (GPCRs); Protease enzymes
- Receptors: Caspase; hERG; Histamine receptor; mAChR; Na+/Ca2+ exchanger; Potassium channel; Caspase
- CAS No.: 2000209-42-5
- Pathways: JAK/STAT signaling; PI3K/Akt/mTOR signaling; Cell cycle/Checkpoint; Apoptosis; Metabolism; Chromatin/Epigenetic; Tyrosine kinase/adaptors; NF-κB
- Targets: Serine/Threonine kinases; Kinase families
- Receptors: MELK; RIPK2; MLCK; CLK2; Pim; PIM1/2/3; DYRK3; smMLCK; CDK
