Products
- Anti-Obesity Compound Library
- GPCR/G Protein-Targeted Compounds
- Immunology/Inflammation-Targeted Compounds
- JAK/STAT-Targeted Compounds
- MAPK-Targeted Compounds
- Membrane Transporter/Ion Channel-Targeted Compounds
- Metabolism-Targeted Compounds
- NF-κB-Targeted Compounds
- Microbiology/Virology-Targeted Compounds
- Neuronal Signaling-Targeted Compounds
- PI3K/Akt/mTOR-Targeted Compounds
- Oxidation-reduction-Targeted Compounds
- Proteases/Proteasome-Targeted Compounds
- Stem Cells/Wnt-Targeted Compounds
- Tyrosine Kinase/Adaptors-Targeted Compounds
- Ubiquitin-Targeted Compounds
Online Inquiry
Pimozide
Cat. No.:
0225LY-0974
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
Pimozide is a dopamine antagonist and diphenylbutylpiperidine derivative used as an antipsychotic; it reduces delusions and tics by inhibiting CNS type 2 dopaminergic receptors and antagonizing 5-HT2 and alpha-adrenergic receptors.
Synonym:
R6238; 2062-78-4; Orap; Opiran; Pimozidum; R-6238; R 6238; 2H-Benzimidazol-2-one, 1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-; 1-(1-(4,4-Bis(p-fluorophenyl)butyl)-4-piperidyl)-2-benzimidazolinone; 1-(4,4-Bis(p-fluorophenyl)butyl)-4-(2-oxo-1-benzimidazolinyl)piperidine; 3-[1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one; 1-[1-[4,4-bis(4-Fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; MFCD00055081; 1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone; 2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-; 1-(1-(4,4-bis(4-fluorophenyl)butyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H)-one; 1-{1-[4,4-bis(4-fluorophenyl)butyl]piperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one
CAS No.:
2062-78-4
Compound CID:
16362
Formula:
C28H29F2N3
Formula Weight:
461.55
Specification
Targets&IC50:
α1-adrenoceptor: 39 nM (Ki); D3: 2.5 nM (Ki); D2: 1.4 nM (Ki); D1: 588 nM (Ki)
Relative Density:
1.1763 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Pimozide can be used in psychiatric research to investigate the blockade of dopamine D2 receptors and its impact on psychotic symptoms.
Library Information
Target:
Potassium channel; Dopamine receptor; Adrenergic receptor; STAT
Receptor:
D2 receptor; Potassium channel; STAT; α1-Adrenergic receptor
Pathways:
JAK/STAT signaling; Stem cell regulation; Membrane transporter/Ion channel; GPCR/G protein signaling; Neuronal signaling
Plate Number:
AOCL-13
Plate Location:
e5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
41 mg/mL; 88.83 mM
