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Obesity Epigenomic Service

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Overview

Understanding the potential role of epigenetics as a key regulator in the development of obesity and its associated complications is becoming increasingly popular. Epigenetic regulation predominantly relies on processes such as histone modification to alter chromatin structure, DNA methylation to influence gene transcription, and miRNA-mediated post-transcriptional control. Analysis of their changes helps deepen the understanding of the complex etiology of obesity, screen multiple obesity-related candidate genes and biomarkers, and open up the possibility of designing targeted preventive and therapeutic strategies.

Fig.1 Major epigenetic regulatory mechanisms. Fig.1 Epigenetic mechanisms. (Wu & Yin, 2022)

Decoding Obesity: Personalized Epigenomic Services

Protheragen provides a one-stop, high-quality obesity epigenomics service based on its leading technology platform, professional research team, and rich bioinformatics analysis experience, helping to achieve innovative results in the field of Obesity Research. We offer flexible service modules to meet different research needs.

Our Technology

We comprehensively and precisely analyze obesity-associated epigenetic modifications based on a variety of advanced and well-established epigenomics technologies:

  • Chromatin immunoprecipitation sequencing (ChIP-seq): This technique is used to study in depth the interactions of specific proteins with genomic DNA, e.g., histone modifications, transcription factor binding sites, etc., and to reveal the activity status of regulatory elements and regulatory networks.
  • Methylation sequencing: This includes the use of sequencing technologies such as reduced representation bisulfite sequencing (RRBS) and whole genome bisulfite sequencing (WGBS) to accurately detect the level of DNA methylation and to reveal the key role of DNA methylation in the regulation of gene expression and the development of obesity.
  • RNA sequencing (RNA-seq): Comprehensively analyze gene expression profiles by RNA-seq, and comprehensively analyze differential expression analysis, pathway enrichment analysis, etc., to reveal obesity-related gene expression changes and their regulatory mechanisms.
  • Other types: In addition to the above, we also provide assays for transposase accessible chromatin with high-throughput sequencing (ATAC-Seq), in situ Hi-C followed by chromatin immunoprecipitation (HiChIP), and other services. By studying chromatin changes, structure, DNA-protein interactions, etc., it helps to screen potential regulatory elements and provides useful information for in-depth analysis of obesity genetic mechanisms.

Based on our rich experience in epigenomics research, we also provide the following two precise services:

Obesity Gene Screening Service

(Protheragen)

The service aims to deeply analyze the epigenetic basis of obesity risk. Through detailed analysis of DNA methylation and histone modifications, we reveal aberrant regulation and analyze obesity mechanisms.

Anti-obesity or Leanness Gene Screening Service

(Protheragen)

We explore candidate genes that are significantly associated with anti-obesity or leanness to better understand the pathogenesis of obesity and support the development of more effective therapeutic strategies.

Sample Requirements

Acceptable sample types include but are not limited to: DNA, RNA, cells, tissues, blood, etc. Different experimental techniques have different sample size requirements.

Workflow

Our specialists communicate with you to meticulously understand your research goals and experimental setup. After that, we customize the optimal experimental plan, including technology selection, sample size determination, experimental group design, etc. Based on a strict quality control system, we process the samples. After that, we reveal their biological significance through various sequencing platforms, raw data quality control, differential methylation region analysis, differential protein binding site analysis, etc. Meanwhile, we also integrate multiple histological data and perform correlation analysis to excavate deeper regulatory mechanisms.

Flow of our obesity epigenomics service. (Protheragen)

Applications

  • Analyzing the dynamics of epigenetic modifications in the development of obesity provides useful information to reveal key regulatory genes and signaling pathways.
  • Epigenomics research helps to discover new obesity-related epigenetic markers, providing a theoretical basis for the development of new therapeutic strategies and drug targets.
  • Combined with epigenetic profiling, it can help develop more precise obesity treatment programs and explore their therapeutic efficacy.

Advantages

  • Professional technical support: Our experienced technical team provides full guidance, including pre-laboratory discussion to final data analysis.
  • High-quality experimental data: A strict quality control system ensures the accuracy and reliability of all analyzed data.
  • In-depth bioinformatics analysis: Our professional bioinformatics analysis team helps to explore the biological meaning behind the data.

One-stop Anti-obesity Research Support

Publication Data

Technology: Epigenome-wide association study (EWAS)

Journal: Diabetology & Metabolic Syndrome

IF: 4.8

Published: 2022

Results: This paper synthesizes several studies in the literature and details the role of epigenetics in obesity research and related advances. Through the analysis of DNA methylation and miRNA-mediated regulation in different biological samples, DNA methylation changes and differentially expressed miRNAs associated with obesity are identified and linked to relevant clinical symptoms. This information will help to explore the underlying mechanisms of obesity and assist in the screening of new targets for early prevention of obesity and the development of targeted therapeutic strategies.

Fig.2 DNA methylation differential analysis. Fig.2 DNA methylation changes in different obese samples. (Wu & Yin, 2022)

Frequently Asked Questions

  1. What information do I need to provide for the consultation?

    Please provide information about your research background, research objectives, sample type, experimental grouping, and proposed technology so that we better design an experimental program for you.

  2. Do you provide customized bioinformatics analysis?

    Yes, our bioinformatics team provides customized data analysis solutions based on your specific research needs.

Protheragen is committed to being the most reliable partner in obesity research. With our advanced technology platform and comprehensive services, we help to explore the epigenetic regulation of obesity and accelerate the research process. Please do not hesitate to contact us should you require further information.

Reference

  1. Wu, F.Y.; Yin, R.X. Recent progress in epigenetics of obesity. Diabetology & Metabolic Syndrome. 2022, 14(1): 171. (CC BY 4.0)

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

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