Overview

The gut is rich in microbiota. These microbiotas may extract energy from fiber digestion to improve the development and maturation of the intestinal and systemic immune systems, thus forming a symbiotic relationship with the human body and working together to maintain the immune stability and balance of the body's intestinal tract. There is a close association between microbial abundance, metabolites, and diet in the development of obesity disorders. Protheragen has specialized gut flora experts to help clients with an in-depth description of the relationship between obesity and gut flora. The impact of changes in gut flora is comprehensively assessed in all aspects from energy absorption, fat storage, gastrointestinal function, satiety, gut-brain axis, and circadian rhythms to gluconeogenesis.

Study on the Effect of Gut Microbiota on Obesity and Its Mechanism

As a biological company focused on obesity research, we provide the following services for a deep understanding and management of obesity issues:

Influence on Energy Absorption

Relying on years of experience in obesity research, our company offers detailed isolation, identification, and characterization services of gut flora to assess energy absorption efficiency. With specialized services to analyze the composition and metabolic activity of the gut microbiota, we help clients analyze the bacteria that contribute to energy extraction and utilization to optimize energy balance.

Influence on Fat Storage

Our services include assessing how the gut microbiota influences adipocyte differentiation and adipose tissue expansion. By identifying specific bacterial species associated with fat storage, we provide customized interventions such as probiotic supplementation or specific dietary modifications to reduce unwanted fat accumulation. Our researchers offer subcutaneous fat distribution testing services to help clients gain a clear understanding of fat distribution throughout the body.

Influence on Gastrointestinal Function

We offer gut health assessment services that focus on how the gut microbiota affects gastrointestinal motility and digestive function. With the help of animal models and in vitro digestive models, our researchers help improve a wide range of gastrointestinal issues by improving the balance of the gut microbiota, thereby promoting overall health.

Influence on Satiety

Our services are designed to analyze how the gut microbiota affects hunger hormones and satiety signaling. By tuning the gut microbiota, we provide strategies to help control appetite and promote healthy eating behaviors, which are critical for weight management.

Influence on Gut-brain Axis

Our company provides professional services to analyze the regulatory mechanisms of the gut-brain axis. Our researchers comprehensively analyze the important role of the gut-brain axis in the occurrence and development of obesity, including how gut microbes influence host behavior through gut hormones, vagal connections, etc. Moreover, our professional biologists provide in-depth research on the regulatory mechanisms of the gut-brain axis to help clients reveal the neurobiological mechanisms behind obesity.

Influence on Gene Expression Related to Obesity

Our services include gene expression analysis to understand how the gut microbiota affects genes associated with obesity. Our researchers use gene microarray or sequencing technology to examine the expression levels of obesity-related genes, including genes involved in fat metabolism, energy balance, inflammatory response, etc. Moreover, we provide association analysis between the gut microbiota and the expression of obesity-related genes to reveal how the microbiota influences the pattern of gene expression. Our company conducts in-depth studies on the interaction mechanisms between specific genes and the gut microbiota, including gene regulation, signaling, and other aspects.

Influence on Circadian Rhythm

Based on animal models and monitoring systems, we provide circadian rhythm assessment services to study how the gut microbiota affects the body's biological clock. By adjusting the gut microbiota and specific lifestyles, we observe sleep quality and daytime alertness in animal models. These services are critical to maintaining a healthy weight and metabolic health.

Influence on Gluconeogenesis

Our services include assessing how the gut microbiota influences gluconeogenic processes in the liver. By optimizing the composition of the gut microbiota, we provide strategies to improve glycemic control and insulin sensitivity, which are critical for the prevention and treatment of obesity and its associated metabolic diseases.

Workflow 

Applications

• Advanced gut microbiota profiling can be used for obesity-related potential microbial target discovery and characterization.
• Advanced gut microbiota profiling plays an important role in the development of anti-obesity therapies.
• Advanced gut microbiota profiling helps to develop anti-obesity agents for the gut microbiota, such as probiotics.

Advantages of Us

• Our company provides gut microbiota profiling in addition to the development of therapeutics based on intestinal targets.
• We utilize advanced gene sequencing technology and bioinformatics tools to provide our clients with precise gut microbiota analysis and deep insights into obesity-related gene expression.
• We provide personalized solutions based on the program information provided by each client, such as gut microbiota composition, genetic background, and lifestyle.

Explore More Obesity-Related Services Together

Publication Data

Frequently Asked Questions

1. How does the gut microbiota influence the mechanisms of obesity?
   • Affects obesity by regulating short-chain fatty acids
   • Affects obesity by regulating bile acids
   • Affects obesity by changing host energy uptake and energy stabilization
   • Affect obesity by modifying inflammation levels
   • Affects obesity by regulating fat accumulation
   • Affect obesity by modifying the endogenous cannabis system
   • Affect obesity by feeding induction factors
2. How to combat obesity based on the gut microbiota?
   • Prevention and treatment of obesity by adjusting the diet structure
   • Control of obesity by supplementation of probiotics
   • Preventing obesity by fecal bacteria transplantation
   • Combating obesity through the application of dietary fiber
   • Control of obesity by plant-active chemicals

Protheragen is committed to providing our clients with a one-stop service for gut microbiology analysis. Our researchers always welcome every client with enthusiasm and professionalism. Feel free to contact us at any time.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Effect Analysis of Dietary Components on the Gut Microbiota
• Genetics Analysis Service of Microbiota in Obesity
• Obesity Microbiota Colonization Studies