Anti-Obesity Compound Library
InquiryOur Anti-Obesity Compound Library Comprehensively Facilitates Your Research
Obesity, as a metabolic disease, is closely related to genetic predisposition, the external environment, individual lifestyle, and inflammatory responses in the body. Obesity exposes individuals to a higher risk of developing a complex array of metabolic diseases, such as type 2 diabetes mellitus (T2DM), cardiovascular disease, and certain types of cancer. In addition, obesity adversely affects key metabolic organs in the body, particularly adipose tissue and skeletal muscle. Excess adipose tissue causes adipocytes to expand in size, which triggers down-regulation of mitochondrial oxidative metabolism, impaired lipid buffering, and exacerbates inflammatory responses in the body.
Protheragen provides a library of anti-obesity compounds containing thousands of compounds that primarily target signaling pathways related to appetite control, fat metabolism, and energy expenditure, making it a useful tool for developing anti-obesity drugs.
Library Information
- A variety of structures and effectiveness
- Covering multiple signaling pathways
- Nuclear magnetic resonance (NMR) and high-performance liquid chromatography (HPLC) identification of purity
- For high-throughput screening and high-content screening
- Customization: specific molecule, plate location, specification, formulation, form
Formulation: Anti-obesity compounds offered as a pre-solution or solid.
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Packing: Our researchers place different concentrations or compounds in different solvents on the corresponding plates, depending on the client's needs.
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Storage: From receipt of the product
| Solution | -20°C | 1 year |
| -80°C | 2 years |
Library Composition
Plate Location
Publication
Technology: Quantitative real-time polymerase chain reaction (RT-PCR), Immunoblotting, Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE)
Journal: Cells
Published: 2021
IF: 5.1
Results: This article focuses on the role and mechanisms of D-mannitol in promoting mitochondrial biosynthesis and browning in adipocytes. The researchers screened a natural product library containing 133 compounds to assess their ability to induce 3T3-L1 preadipocyte differentiation. D-mannitol was found to significantly increase mitochondrial content in differentiated 3T3-L1 adipocytes. D-mannitol-treated adipocytes exhibited browning characteristics, including upregulation of the expression of a range of factors associated with brown fat, such as Tbox protein 1 (Tbx1), transmembrane protein 26 (Tmem26), CBP/p300-interacting transactivator 1 (Cited1) a, PR domain containing 16 (PRDM16) and PPARγ coactivator 1α (PGC1α). The findings contribute to an in-depth understanding of the molecular mechanisms of adipocyte browning and provide a theoretical basis for the development of novel anti-obesity drugs.
Fig.1 Effect of D-mannitol on the mitochondrial content of differentiated adipocytes. (Jeon, et al., 2021)
Applications
- Anti-obesity compound library can be used to screen compounds with potential anti-obesity activity rapidly.
- Anti-obesity compound library can be used as a research tool to explore the pathogenesis of obesity.
- Anti-obesity compound library can be used to discover drug targets and provide new ideas for the development of anti-obesity drugs.
Advantages of Us
- Our company provides a wealth of documented information, including compound structure and biological activity information.
- Our company provides customized libraries of anti-obesity compounds to meet our clients' research needs.
- Our anti-obesity compound library is characterized by high purity, structural clarity, and high potency.
Frequently Asked Questions
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Is the position on the plate where the molecules are placed optional?
Sure! Our company supports clients in choosing their targets, containers, and molecule placement. Moreover, the empty plate position is also selectable.
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How to rapidly screen compounds with potent anti-obesity activity from a large library of compounds?
Our company uses high-throughput screening technology, utilizing automated tools and advanced detection techniques to significantly improve screening efficiency. Our company has strict screening standards and validation processes, including cellular experiments and animal experiments, to ensure the accuracy of the screening results.
Protheragen provides a professional anti-obesity compound library to clients. Anti-obesity compound library is an important drug development tool with a wide range of applications in the field of obesity. Please feel free to contact us if you have customization needs or other questions.
Reference
- Jeon, H.J.; et al. D-mannitol induces a brown fat-like phenotype via a β3-adrenergic receptor-dependent mechanism. Cells. 2021, 10(4): 768. (CC BY 4.0)