Overview of Arterial Blood Pressure

In animal model studies, arterial blood pressure is a commonly evaluated parameter. It is the force that the blood flow exerts on the arterial wall. Systemic arterial blood pressure has three components: systolic, mean, and diastolic arterial blood pressure. Systolic arterial blood pressure is the highest intra-arterial pressure in each cardiac cycle. Diastolic arterial blood pressure is the lowest before the next heartbeat. Mean arterial blood pressure is the average area under the pulse pressure waveform. Because diastole takes up more time in each cardiac cycle, it's closer to diastolic arterial blood pressure. Therefore, Protheragen provides testing services for accurately determining arterial blood pressure. It is important for the Obesity Physiology and Biochemistry Analysis Service during the experiment.

Given that obesity commonly brings about cardiovascular complications, by leveraging our service to measure arterial pressure, we gain in-depth insights into the physiological mechanisms associated with obesity, which in turn may help us identify new therapeutic targets. During the process of our anti-obesity therapy development, our service enables us to conduct real-time assessments of how a therapy affects arterial pressure. This is of utmost importance for us to evaluate the safety and efficacy of the therapy. In our preclinical studies, the service's unique features, such as the ability to monitor freely-moving conscious animals and provide vascular access for drug administration, offer us a more realistic experimental environment and provide us with crucial data for the pre-clinical evaluation of our anti-obesity therapeutics.

In Anti-obesity Battles, Our Service Makes Arterial Blood Pressure Data a Powerful Weapon

At Protheragen, our arterial pressure testing service presents an eminently efficacious and multifaceted approach for the precise quantification of arterial pressure. Employing indwelling fluid-filled catheters, we implant them into the aorta through either the femoral or carotid artery. This methodology permits direct and uninterrupted measurements of arterial pressure, thereby furnishing dependable and real-time data. The catheter is linked to a strain-gauge manometer, which accurately transduces the pressure signal into an electrical one. Subsequently, this electrical signal is observed and archived using either analog or digital recorders, guaranteeing the integrity and accessibility of the data for in-depth exploration. Once the catheters are exteriorized and securely fastened, they are tethered to a swivel device on the animal's enclosure. This distinctive configuration allows the animals to move unconstrainedly while the arterial pressure is being monitored.

Our service offers direct and continuous measurements of arterial pressure, affording a comprehensive perspective on the cardiovascular state. Secondly, apart from pressure monitoring, it facilitates vascular access. This characteristic bestows greater flexibility upon experiments, enabling diverse interventions such as the administration of specific pharmacological agents. Our researchers are able to acquire high-quality data within a more natural and physiological milieu, enhancing the pertinence and dependability of their discoveries.

Workflow

Applications

• Our service can be used to accurately measure arterial blood pressure, which helps in precisely assessing the pharmacological effects of drugs during experiments.
• By monitoring the changes in arterial blood pressure during anti-obesity treatment, the safety and efficacy of the treatment can be evaluated.
• Based on the in-depth understanding of obesity-related physiological mechanisms, by analyzing arterial blood pressure data, it is possible to discover new therapeutic targets.

Advantages

• We directly measure the pressure inside the artery, eliminating errors associated with non-invasive detection methods.
• We uninterruptedly monitor to capture dynamic blood pressure changes.
• Our method allows for direct drug administration through the catheter to observe the dynamic blood pressure response to drugs in real-time.

Publication Data

Frequently Asked Questions

1. What other methods are there for arterial blood pressure testing?
   • Tail cuff
   • Millar solid-state catheters
   • Implanted telemetry systems
2. How does obesity affect blood pressure?

   When it comes to obesity-related hypertension, higher circulating plasma volume, greater cardiac output, and increased peripheral vascular resistance cause blood pressure to go up.

Protheragen's service offers high-reliability and high-validity data support for obesity-related cardiovascular research through precise monitoring technology, assurance of physiological authenticity, multi-functional vascular access, and suitability for pre-clinical research. If you want to transform complex blood pressure parameters into actionable R&D insights, facilitating target discovery and efficacy optimization of anti-obesity therapies, contact us.

All of our services and products are intended for preclinical research use only and cannot be used to diagnose, treat or manage patients.

• Blood Lipid Testing Service
• Body Mass Distribution Testing Service
• Insulin Testing Service