Metabolism-Targeted Compounds

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Metabolism-Targeted Compounds Applications Advantages Publication FAQs

Overview

Metabolism is a fundamental process for sustaining life activity and involves biochemical reactions that convert carbohydrates, lipids, and proteins into energy. This process plays a key role in metabolic diseases such as obesity, diabetes, cardiovascular disease, and cancer. Protheragen provides high-purity products of metabolism-related compounds. These products are widely used in the fields of drug screening, cell induction, and mechanism research, providing strong support for your research.

Fig.1 Scheme depicting how the imbalance between the input and the output leads to obesity as an outcome. Fig.1 Obesity due to an imbalance between inputs and outputs. (Uranga & Keller, 2019)

Enabling Obesity Research and Target Discovery

Our company provides high-purity metabolism-related compounds, including fatty acids, amino acid derivatives, biogenic amines, glucose metabolism intermediates, endogenous metabolites, fatty acid synthase inhibitors, etc., covering the core pathways of glucolipid metabolism, energy homeostasis, and signaling. Examples of our high-quality inhibitors include, but are not limited to:

SREBP Activation Inhibitor	ACSS2 Inhibitor	FASN Inhibitor
Ras Inhibitor	KRAS-PDEδ Inhibitor	FTase Inhibitor
SCD1 Inhibitor	SCD Inhibitor	Non-selective Lipase Inhibitor
PI3K Broad-spectrum Inhibitor	COX1 & COX2 Inhibitor	FAAH Inhibitor

Our product matrix provides comprehensive coverage of diversified research targets, covering the following:

5-HT receptor	Acetyl-CoA carboxylase	AChR	Acyltransferase
Adenosine receptor	AdipoR	Adrenergic receptor	Akt
AMPK	Androgen receptor	Antibacterial	Antibiotic
Antifungal	Antineoplastic and immunosuppressive antibiotics		Antioxidant
Apoptosis	ATP citrate lyase	Aurora kinase	Autophagy
Calcium channel	CaMK	Cannabinoid receptor	Carbohydrate metabolism
Casein kinase	CDK	CETP	Chk
COVID-19	COX	CPT	Dehydrogenase
DNA/RNA synthesis	DNA-PK	Dopamine receptor	Dyes
EGFR	Endogenous metabolite	Epoxide hydrolase	ERK
FAAH	Fatty acid synthase	Ferroptosis	FLT
FOX	Fungal	FXR	Glucocorticoid receptor
Glucosidase	Glutathione peroxidase	GPR	GSK-3
HDAC	Hedgehog/Smoothened	HIF	HIF/HIF prolyl-hydroxylase
Histamine receptor	HIV protease	HMG-CoA reductase	HSV
Hydroxylase	IL receptor	Influenza virus	Interleukin
JNK	Lipase	Lipid	Lipoxygenase
Liver X receptor	MAGL	MAO	MAPK
Mdm2	Mitochondrial metabolism	Mitochondrial pyruvate carrier	Mitophagy
MMP	Monocarboxylate transporter	mTOR	MyD88
NF-κB	NO synthase	Norepinephrine	NOS
Nrf2	Pyroptosis	P2Y receptor	p38 MAPK
P450	p53	PAI-1	Parasite
PDE	PDHK	PDK	PGC-1α
Phosphatase	Phospholipase	PI3K	PKA
PKC	Potassium channel	PPAR	Prostaglandin receptor
Proton pump	PTEN	RAAS	Reverse transcriptase
Ras	Reductase	Retinoid receptor	RSV
ROR	ROS	SCD	S6 Kinase
Serine protease	SGLT	Sirtuin	Smo
Sodium channel	Src	Tyrosine kinases	TLR
TNF	TNF-alpha	Transferase	transporter
TRP/TRPV channel	Tyrosinase	Vitamin	VEGFR
Wnt/beta-catenin	Xanthine oxidase

Applications

Mechanistic Elucidation & Pathogenesis: Our high-quality metabolism-related compounds can be used for screening and mechanistic studies of anti-obesity molecules and exploring the molecular pathogenesis of obesity.
Targeted Drug Discovery: Our high-quality metabolism-related compounds can be used to construct phenotypic screening models for rapid discovery and validation of novel metabolic modulators.
Metabolomics Research Tool: Our products serve as specialized tools for metabolomics research, enabling quantitative metabolite analysis and structural identification of unknown metabolites.

Advantages of Us

Diversified Options

Our products cover a broad spectrum of metabolic pathways, targets, and receptors, addressing complex research needs ranging from fundamental mechanism exploration to drug screening.

Precise Targeting

Leveraging metabolomics big data screening, the company focuses on core metabolic nodes related to obesity, significantly enhancing drug discovery efficiency and success rates.

Modification Services

Our company provides compound structure modification, stability testing, and proprietary library design to accelerate the progress of client projects.

Publication

Title: Association between metabolite profiles, metabolic syndrome, and obesity status

Journal: Nutrients, 2016

DOI: https://doi.org/10.3390/nu8060324

Summary: The authors used metabolomic analysis to reveal metabolic differences between normal weight (NW) and overweight/obese (Ov/Ob) individuals and to elucidate the underlying mechanisms of obesity-related metabolic abnormalities. Obesity and metabolic syndrome patients have been found to have significantly abnormal levels of metabolites such as long-chain glycerophospholipids, and these changes are strongly associated with lipid metabolism disorders and decreased insulin sensitivity. Levels of branched-chain amino acids (BCAAs) and acylcarnitines correlate with healthy metabolic status, and their decline may indicate impaired metabolic function.

Fig.2 Metabolite patterns. Fig.2 Metabolite models for gene information studies. (Allam-Ndoul, et al., 2016)

Customer Review

Integrated Pathway Analysis
"This metabolic compound library is exceptionally well-designed, comprehensively covering multiple metabolism-related targets. It has significantly streamlined our translational process from metabolomics data to functional validation."— Dr. T* B***

Reliability in Enzyme Assays
"Beyond its exceptional structural diversity, Protheragen's metabolic compound library most importantly provides highly detailed molecular activity data and quality reports. This greatly facilitates in-depth analysis of our high-throughput screening results and precisely guides subsequent lead compound optimization and experimental design."— C. N* P***

Frequently Asked Questions

Is it possible to customize compound libraries?

Yes, we offer customized compound libraries service to design and synthesize the desired compound libraries according to your specific needs.
How to dissolve these compounds? What solvents are recommended?

Most small molecules are soluble in DMSO, and some are soluble in water, ethanol, or PBS. For insoluble compounds, try sonication, heating, or the use of co-solvents. For specific solubilization methods, please refer to the product manual or consult our technical support team.
Is the compound library suitable for structure optimization?

Absolutely. Our compound library contains numerous molecules with similar chemical skeletons but slightly different activities. Following high-throughput screening, it provides information support for structural modification and optimization of lead compounds.

The high-quality metabolic compounds Protheragen provides are a great choice for your obesity research. With our metabolism-related compound products, clients conduct scientific research on obesity and related metabolic diseases more efficiently. Please feel free to contact us!

References

Allam-Ndoul, B.; et al. Association between metabolite profiles, metabolic syndrome, and obesity status. Nutrients. 2016, 8(6): 324. (CC BY 4.0)
Uranga, R.M.; Keller, J.N. The complex interactions between obesity, metabolism, and the brain. Frontiers in Neuroscience. 2019, 13: 513. (CC BY 4.0)