Obesity-related Proteins and Peptides

The rapid increase in obesity and associated metabolic conditions, including type 2 diabetes, metabolic dysfunction-associated steatohepatitis (MASH), and cardiovascular disease, has driven metabolic research into an unprecedented phase. From early insights into energy homeostasis to the recent clinical success of multi-target GLP-1, GIP, and glucagon receptor agonists, proteins and peptides remain the primary tools for dissecting physiological pathways and engineering therapeutics.

Metabolic control relies on an interconnected network of gut hormones, adipokines, central appetite signals, and peripheral tissue regulators. To support academic research groups and drug discovery teams in target validation, high-throughput screening, and structural analysis, Protheragen provides a comprehensive portfolio of high-purity, biologically active obesity-related proteins and peptides.

Obesity-Related Proteins and Peptides: Unlocking Metabolic Regulation and Drug Discovery

Our selection of recombinant proteins and synthetic peptides supports the study of obesity-related mechanisms, metabolic signaling, and associated biological processes across a range of research applications.

• Gut-Brain Axis and Gastrointestinal Hormones

Includes glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), peptide YY (PYY), oxyntomodulin, and ghrelin variants. These molecules support research into glucose-dependent insulin secretion, appetite and satiety signaling, and receptor interactions. Available forms may include native sequences and modified analogs, depending on product specifications.

• Adipokines and Systemic Metabolic Regulators

Features leptin, adiponectin, resistin, retinol-binding protein 4 (RBP4), and visfatin. These proteins are relevant to studies of adipose tissue function, insulin sensitivity, energy homeostasis, and inflammation. Product-specific information on biological activity, oligomeric state, and characterization is available where provided by the supplier.

• Fibroblast Growth Factors and Metabolic Signaling

Includes fibroblast growth factor 21 (FGF21), fibroblast growth factor 19 (FGF19), and the co-receptor β-Klotho. These molecules are involved in the regulation of glucose and lipid metabolism and support research into fatty liver disease, metabolic dysfunction, and energy homeostasis.

• Central Melanocortin and Neuropeptide Pathways

This range features pro-opiomelanocortin (POMC)-derived peptides, agouti-related protein (AgRP), neuropeptide Y (NPY), and melanocortin 4 receptor (MC4R)-associated molecules, offering resources for examining hypothalamic neural circuits and neuroendocrine control of feeding patterns.

Applications

• Structural and Biophysical Characterization: Applying X-ray crystallography, cryogenic electron microscopy (cryo-EM), surface plasmon resonance (SPR), and bio-layer interferometry (BLI) to examine molecular structures, binding affinity, and receptor engagement.
• Preclinical Metabolic Assessment: Using animal models to characterize changes in feeding behavior, body weight, body composition, and energy expenditure following acute or sustained interventions.
• Glucose and Lipid Metabolism Studies: Examining cellular responses to insulin, liver glucose output, and lipid deposition to characterize metabolic changes in relevant in vitro models.
• Adipocyte and Hepatocyte Model Development: Exploring how selected adipokines and growth factors influence adipocyte differentiation and cellular processes associated with metabolic dysfunction-associated steatohepatitis (MASH).
• Peptide Candidate Assessment: Characterizing engineered multi-agonist peptides and benchmarking their functional performance against established reference compounds.

Advantages

Publication Data

Customer Review

Frequently Asked Questions

1. Which host expression systems are used for your metabolic proteins?

   Mammalian systems, including HEK293 and CHO cells, are primarily used for proteins requiring complex post-translational modifications. Escherichia coli is generally selected for simpler protein domains that do not require glycosylation.

2. What formatting options are available for reconstituted stability?

   Products are supplied as lyophilized powders with optimized carrier-free buffer compositions, ensuring rapid reconstitution and minimal aggregation upon storage.

3. Do you offer carrier-free options suitable for in vivo animal studies?

   Yes, all in vivo grade products are formulated without BSA, HSA, or additives that could trigger unwanted immune or physiological responses in test subjects.

4. What is the typical shelf life and recommended storage condition for these products?

   Lyophilized products are stable for at least 12 months when stored at -20°C to -80°C. Once reconstituted, aliquots should be stored at -80°C to avoid repeated freeze-thaw cycles.

Translating complex metabolic mechanisms into effective therapeutics requires biological tools designed with precision and structural fidelity. Whether you are probing central appetite circuits, mapping metabolic growth factor signaling, or validating novel multi-target therapeutics, the obesity-related proteins and peptides at Protheragen offer the reliability required for breakthrough discovery. We welcome you to contact us to discuss tailored solutions for your research pipeline.