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AZ960
Cat. No.:
0225LY-0704
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
AZ960 acts as a high-efficiency, ATP-competitive inhibitor of JAK2, featuring an IC50/Ki of less than 3 nM and 0.45 nM, respectively.
Synonym:
AZ 960; 905586-69-8; (S)-5-fluoro-2-((1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)nicotinonitrile; 5-Fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]-3-pyridinecarbonitrile; 3-Pyridinecarbonitrile, 5-fluoro-2-(((1S)-1-(4-fluorophenyl)ethyl)amino)-6-((5-methyl-1H-pyrazol-3-yl)amino)-; 5-fluoro-2-[[(1S)-1-(4-fluorophenyl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile; 5-fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile
CAS No.:
905586-69-8
Compound CID:
25099184
Formula:
C18H16F2N6
Formula Weight:
354.36
Specification
Targets&IC50:
JAK2: <3 nM; JAK2: 0.45 nM(Ki)
Relative Density:
1.37 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AZ960 can be used in hematological research to examine the selective inhibition of JAK2 and its role in myeloproliferative signaling.
Library Information
Target:
Virus protease; JAK; Parasite protein
Receptor:
JAK2; Parasite protein; Virus protease
Pathways:
JAK/STAT signaling; Angiogenesis; Apoptosis; Chromatin/Epigenetic; Microbiology/Virology; Stem cell regulation
Plate Number:
AOCL-10
Plate Location:
a11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 705.5 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
3 mg/mL; 8.47 mM
ALogP:
4.495
HBA_Count:
2
HBD_Count:
3
Rotatable Bond:
5
