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FM-381
Cat. No.:
OB0225WX-2761
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
Add to basket
Product Overview
Description:
FM-381 acts as a specific and reversible covalent inhibitor of JAK3, featuring an IC50 of 127 pM and demonstrating a minimum of 400-fold selectivity over other Janus kinase family members such as JAK1, JAK2, and TYK2.
Synonym:
2226521-65-7; FM381; (E)-2-cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide; (E)-2-cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide; 2-Cyano-3-(5-(1-cyclohexyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-2-yl)furan-2-yl)-N,N-dimethylacrylamide; 2-Cyano-3-[5-(3-Cyclohexyl-3,5,8,10-Tetrazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-Pentaen-4-Yl)furan-2-Yl]-~{n},~{n}-Dimethyl-Prop-2-Enamide
CAS No.:
2226521-65-7
Compound CID:
122197584
Formula:
C24H24N6O2
Formula Weight:
428.49
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
FM-381 is utilized in chemical biology research as a potent and selective covalent inhibitor of the JAK3 kinase to investigate the regulation of immune signaling and the specificity of cysteine-targeting inhibitors.
Library Information
Target:
JAK
Receptor:
JAK3
Pathways:
JAK/STAT
Plate Number:
L6700-10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
20 mg/mL; 46.68 mM
Ethanol Max Solubility:
2 mg/mL
ALogP:
4.084
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
4
