NVP-BSK805 2HCl

Cat. No.: OB0225WX-2510

Appearance: Solid

Purity: ≥95%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: NVP-BSK805 2HCl is a potent, ATP-competitive JAK2 inhibitor (IC50: 0.5 nM) that displays more than 20-fold selectivity over other JAK family members such as JAK1, JAK3, and TYK2.

Synonym: BSK805; 1092499-93-8 (free base); NVP-BSK805 dihydrochloride; BSK805; NVP-BSK805 (hydrochloride); NVP-BSK805 (dihydrochloride); 4-[[2,6-difluoro-4-[3-(1-piperidin-4-ylpyrazol-4-yl)quinoxalin-5-yl]phenyl]methyl]morpholine;dihydrochloride; 8-[3,5-Difluoro-4-(4-morpholinylmethyl)phenyl]-2-[1-(4-piperidinyl)-1H-pyrazol-4-yl]quinoxaline dihydrochloride; BSK 805; JAK2 inhibitor; NVP-BSK805 2HCl (BSK-805); 8-(3,5-difluoro-4-(morpholinomethyl)phenyl)-2-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxaline dihydr; 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-[1-(piperidin-4-yl)pyrazol-4-yl]quinoxaline dihydrochloride; AS-16275; 4-(2,6-Difluoro-4-(3-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)quinoxalin-5-yl)benzyl)morpholine dihydrochloride; 4-[[2,6-Difluoro-4-[3-(1-piperidin-4-ylpyrazol-4-yl)quinoxalin-5-yl]phenyl]methyl]morpholine dihydrochloride; 8-{3,5-Difluoro-4-[(morpholin-4-yl)methyl]phenyl}-2-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]quinoxaline--hydrogen chloride (1/2)

CAS No.: 1092499-93-8 (free base)

Compound CID: 57339395

Formula: C₂₇H₂₈F₂N₆O·2HCl

Formula Weight: 563.47

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: NVP-BSK805 2HCl is applied in hematology research as a potent and selective JAK2 inhibitor to investigate the suppression of STAT5 phosphorylation in models of myeloproliferative neoplasms.