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JAK2 Inhibitor V
Cat. No.:
0225LY-1360
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
JAK2 Inhibitor V serves as a specialized inhibitor of Jak2 that suppresses the autophosphorylation of both the wild-type (WT) and V617F mutant forms of the kinase in a dose-dependent manner.
Synonym:
JAK2 Inhibitor V Z3; Z3;NSC42834; 195371-52-9; NSC 42834; JAK2 Inhibitor V, Z3; 2-methyl-1-phenyl-4-(pyridin-2-yl)-2-(2-(pyridin-2-yl)ethyl)butan-1-one; 2-methyl-1-phenyl-4-pyridin-2-yl-2-(2-pyridin-2-ylethyl)butan-1-one; 2-methyl-1-phenyl-4-(pyridin-2-yl)-2-[2-(pyridin-2-yl)ethyl]butan-1-one
CAS No.:
195371-52-9
Compound CID:
238484
Formula:
C23H24N2
Formula Weight:
344.45
Specification
Targets&IC50:
JAK2 (V617F): 28 μM (IC50); JAK2 (WT): 15 μM (IC50)
Relative Density:
1.106 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
JAK2 Inhibitor V can be used in biochemical research to examine the selective targeting of the JAK2 kinase domain in signaling assays.
Library Information
Target:
JAK2; JAK2 (V617F)
Receptor:
JAK2; JAK2 (V617F)
Pathways:
JAK/STAT signaling; Stem cell regulation; Angiogenesis; Chromatin/Epigenetic
Plate Number:
AOCL-18
Plate Location:
d10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
250 mg/mL; 725.79 mM
ALogP:
4.718
HBA_Count:
3
HBD_Count:
0
Rotatable Bond:
8
