KRN-633

Cat. No.: OB0225WX-2257

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and LC-MS.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: KRN-633 is a selective urea-based inhibitor of the vascular endothelial growth factor receptor (VEGFR) family, exhibiting IC50 values of 170 nM, 160 nM, and 125 nM for VEGFR1, 2, and 3.

Synonym: KRN633; 286370-15-8; KRN 633; K00589a; VEGF receptor tyrosine kinase inhibitor III; 1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea; 1-{2-chloro-4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-3-propylurea; 1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea; 1-(2-chloro-4-((6,7-dimethoxyquinazolin-4-yl)oxy)phenyl)-3-propylurea; N-(2-chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-N'-propylurea; Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl]-N'-propyl-; Urea, N-(2-chloro-4-((6,7-dimethoxy-4-quinazolinyl)oxy)phenyl)-N'-propyl-; N-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N'-propylurea; MFCD14155620; N-[2-Chloro-4-[(6,7-dmethoxy-4-qunazolnyl)oxy]phenyl]-n'-propylurea; N-{2-Chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-phenyl}-N'-propylurea

CAS No.: 286370-15-8

Compound CID: 9549295

Formula: C₂₀H₂₁ClN₄O₄

Formula Weight: 416.86

Specification

Targets&IC50: VEGFR1: 170 nM; VEGFR3: 125 nM; VEGFR2: 160 nM

Relative Density: 1.321 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: KRN-633 is employed in cardiovascular and oncology research as a potent inhibitor of VEGFR tyrosine kinases to investigate the inhibition of vascular permeability and the blockage of tumor-induced angiogenesis.