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Cerdulatinib hydrochloride
Cat. No.:
0225LY-1340
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
Cerdulatinib hydrochloride is an orally active, multi-target tyrosine kinase inhibitor with high potency against Syk and the JAK family (JAK1/2/3 and TYK2).
Synonym:
Cerdulatinib; PRT2070; PRT062070 hydrochloride; 1369761-01-2; Cerdulatinib HCl; Cerdulatinib HCl salt; RVT-502 hydrochloride; 4-(cyclopropylamino)-2-[4-(4-ethylsulfonylpiperazin-1-yl)anilino]pyrimidine-5-carboxamide;hydrochloride; Cerdulatinib (hydrochloride); 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide (hydrochloride); 5-Pyrimidinecarboxamide, 4-(cyclopropylamino)-2-((4-(4-(ethylsulfonyl)-1-piperazinyl)phenyl)amino)-, hydrochloride (1:1); 4-(Cyclopropylamino)-2-((4-(4-(ethylsulfonyl)piperazin-1-yl)phenyl)amino)pyrimidine-5-carboxamide hydrochloride
CAS No.:
1369761-01-2
Compound CID:
56960607
Formula:
C20H28ClN7O3S
Formula Weight:
482
Specification
Targets&IC50:
Syk: 32 nM; JAK3: 8 nM; TYK2: 0.5 nM; JAK1: 12 nM; JAK2: 6 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Cerdulatinib hydrochloride can be used in hematological oncology to study the dual inhibition of JAK and SYK signaling pathways.
Library Information
Target:
JAK; Syk; MLK; c-Fms; Tyrosine kinases
Receptor:
ARK5; c-Fms; JAK; MLK1; MST1; Syk; Tyk2
Pathways:
Angiogenesis; Chromatin/Epigenetic; Stem cell regulation; JAK/STAT signaling; MAPK; Tyrosine kinase/adaptors
Plate Number:
AOCL-18
Plate Location:
b7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
4.82 mg/mL; 10 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
ALogP:
1.862
HBA_Count:
5
HBD_Count:
3
Rotatable Bond:
8
