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DMH-1
Cat. No.:
OB0125LY-069
Appearance:
Solid
Purity:
99.9%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
DMH-1 is a small molecule compound that blocks BMP signaling by inhibiting the phosphorylation activity of Smad1 and Smad5.
Synonym:
1206711-16-1; DMH-1;DMH1; DMH 1; 4-[6-(4-Propan-2-yloxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline; 4-[6-[4-(1-Methylethoxy)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline; 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
CAS No.:
1206711-16-1
Compound CID:
50997747
Formula:
C24H20N4O
Formula Weight:
380.44
Specification
Targets & IC50:
ALK2: 107.9 nM
Relative Density:
1.24 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
DMH-1 can be used to explore the role of BMP in different physiological and pathological conditions and its importance in cell differentiation, tissue formation and development.
Library Information
Targets:
ALK; TGF-beta/Smad; Autophagy
Receptors:
ALK2; Autophagy; TGF-β receptor
Pathways:
Angiogenesis; Autophagy; Tyrosine kinase/adaptors; Stem cells
Plate Number:
AOCL-3
Plate Location:
c7
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
12.5 mg/mL; 32.86 mM
Water Max Solubility:
1 mg/mL
Ethanol Max Solubility:
1 mg/mL
Saline Max Solubility:
1.25 mg/mL; 3.29 mM
ALogP:
4.036
HBA_Count:
4
HBD_Count:
0
Rotatable Bond:
4
