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RAF265
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Cat. No.:
OB0125LY-074
Size:
1 mg; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg
CAS No.:
927880-90-8
Compound CID:
11656518
Specification
Description:
RAF265 is a small molecule compound with potent inhibitory effects on VEGFR2 phosphorylation.
Formula Weight:
518.41
Stability:
3 years in powder form.
Applications:
RAF265 can be used for melanoma and other tumor disease studies related to the RAF signaling pathway.
Storage:
Storage at -20°C.
Formula:
C24H16F6N6O
Appearance:
Solid
Purity:
99.5%
Identity:
Confirmed by NMR, HPLC, and LC-MS.
Targets&IC50:
C-Raf: 3-60 nM; B-Raf: 3-60 nM; VEGFR2: 30 nM (EC50)
Relative Density:
1.50 g/cm3
Library Information
Plate Number:
AOCL-7
Plate Location:
f6
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Angiogenesis; Autophagy; Apoptosis; Tyrosine kinase/adaptors; MAPK
Targets:
Apoptosis; VEGFR; Raf; Autophagy
Receptors:
Apoptosis; Autophagy; B-Raf; Raf; VEGFR; VEGFR2
DMSO Max Solubility (mg/mL):
51.8 mg/mL
DMSO Max Solubility (mM):
100 mM
Ethanol Max Solubility (mg/mL):
10.4 mg/mL
Ethanol Max Solubility (mM):
20 mM
ALogP:
6.469
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
7