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AZ7550
Cat. No.:
0225LY-0785
Purity:
≥97%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
AZ7550 is an active metabolite of AZD9291 that inhibits IGF1R activity with an IC50 of 1.6 μM.
Synonym:
1421373-99-0; Osimertinib metabolite M3; N-[4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]-2-[methyl-[2-(methylamino)ethyl]amino]phenyl]prop-2-enamide; 2-Propenamide, N-(4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-; N-(4-Methoxy-5-((4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl)amino)-2-(methyl(2-(methylamino)ethyl)amino)phenyl)-2-propenamide
CAS No.:
1421373-99-0
Compound CID:
71496459
Formula:
C27H31N7O2
Formula Weight:
485.58
Specification
Targets&IC50:
FLT3: 302 nM ; FAK: 995 nM ; FES: 449 nM ; PYK2: 2288 nM ; Ack1: 156 nM ; INSR: 1256 nM ; BLK: 977 nM ; ALK: 420 nM ; Brk: 843 nM ; MNK2: 228 nM ; MLK1: 88 nM ; FLT4: 1784 nM ; IGF-1R: 1.6 μM ; ERB4: 195 nM ; TEC: 1317 nM ; IRR: 840 nM
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AZ7550 can be used in pharmacology to study the active metabolite of AZD9291 and its impact on EGFR-mutated cancer signaling.
Library Information
Target:
MNK; ALK; ACK; BTK; PYK2; IGF-1R; Tyrosine kinases; MLK; EGFR; FAK; FLT
Receptor:
ACK1; ALK; BLK; BRK; BTK; EGFR; ErbB4; FAK; FLT3; FLT4; IGF-1R; INSR; MLK1; MNK2; PYK2; TEC; Txk
Pathways:
Angiogenesis; Metabolism; Cytoskeletal signaling; JAK/STAT signaling; MAPK; Tyrosine kinase/adaptors
Plate Number:
AOCL-11
Plate Location:
b4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
2mM DMSO
DMSO Max Solubility:
2.56 mg/mL; 5.27 mM
