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GSK-1070916
Cat. No.:
OB0125LY-075
Appearance:
Solid
Purity:
98.5%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
GSK-1070916 is a reversible and ATP-competitive inhibitor that inhibits of MEK kinase in the MAPK signaling pathway.
Synonym:
942918-07-2; GSK-1070916A; 3-(4-(4-(2-(3-( (Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea; N'-[4-[4-[2-[3-[ (Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethyl-1H-pyrazol-3-yl]phenyl]-N,N-dimethylurea; 3-[4-[4-[2-[3-[ (Dimethylamino)methyl]phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-ethylpyrazol-3-yl]phenyl]-1,1-dimethylurea; 3-(4-(4-(2-(3-( (Dimethylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-ethyl-1H-pyrazol-3-yl)phenyl)-1,1-dimethylurea
CAS No.:
942918-07-2
Compound CID:
46885626
Formula:
C30H33N7O
Formula Weight:
507.63
Specification
Targets & IC50:
Aurora B-INCENP: 3.5 nM; Aurora C-INCENP: 6.5 nM
Relative Density:
1.21 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
GSK-1070916 is mainly for tumor-targeted drug development, especially for those cancer types that depend on the MAPK pathway.
Library Information
Targets:
Aurora kinase; AMPK; Tie-2; FLT; Apoptosis
Receptors:
Apoptosis; Aurora B-INCENP; Aurora C-INCENP; Aurora kinase; FLT1; SIK; Tie-2
Pathways:
Angiogenesis; Chromatin/Epigenetic; Cell cycle/Checkpoint; Apoptosis; Tyrosine kinase/adaptors; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-9
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
102 mg/mL; 200.93 mM
Water Max Solubility:
1 mg/mL
Ethanol Max Solubility:
8 mg/mL; 15.8 mM
