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GSK-1070916
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Cat. No.:
OB0125LY-075
Size:
1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg
CAS No.:
942918-07-2
Compound CID:
46885626
Specification
Description:
GSK-1070916 is a reversible and ATP-competitive inhibitor that inhibits of MEK kinase in the MAPK signaling pathway.
Formula Weight:
507.63
Stability:
3 years in powder form.
Applications:
GSK-1070916 is mainly for tumor-targeted drug development, especially for those cancer types that depend on the MAPK pathway.
Storage:
Storage at -20°C.
Formula:
C30H33N7O
Appearance:
Solid
Purity:
98.5%
Identity:
Confirmed by NMR and HPLC.
Targets&IC50:
Aurora B-INCENP: 3.5 nM; Aurora C-INCENP: 6.5 nM
Relative Density:
1.21 g/cm3
Library Information
Plate Number:
AOCL-9
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Angiogenesis; Chromatin/Epigenetic; Cell cycle/Checkpoint; Apoptosis; Tyrosine kinase/adaptors; PI3K/Akt/mTOR signaling
Targets:
Aurora kinase; AMPK; Tie-2; FLT; Apoptosis
Receptors:
Apoptosis; Aurora B-INCENP; Aurora C-INCENP; Aurora kinase; FLT1; SIK; Tie-2
DMSO Max Solubility (mg/mL):
102 mg/mL
DMSO Max Solubility (mM):
200.93 mM
Water Max Solubility (mg/mL):
1 mg/mL
Ethanol Max Solubility (mg/mL):
8 mg/mL
Ethanol Max Solubility (mM):
15.8 mM