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Abrocitinib
Cat. No.:
OB0125LY-078
Appearance:
Solid
Purity:
99.9%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Abrocitinib is a specific and orally-active JAK1 inhibitor that interferes with cytokine signaling by inhibiting JAK1 to modulate immune cell function.
Synonym:
1622902-68-4; PF-04965842; Cibinqo; N-[cis-3-[Methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide; N-[3-[Methyl (7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]propane-1-sulfonamide; 1-Propanesulfonamide, N-(cis-3-(methyl-7H-pyrrolo (2,3-d)pyrimidin-4-ylamino)cyclobutyl)-; N-(3-(Methyl (7H-pyrrolo (2,3-d)pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide, cis-; N-(cis-3-(Methyl (7H-pyrrolo (2,3-d)pyrimidin-4-yl)amino)cyclobutyl)-propane-1-sulfonamide
CAS No.:
1622902-68-4
Compound CID:
78323835
Formula:
C14H21N5O2S
Formula Weight:
323.41
Specification
Targets & IC50:
JAK2: 803 nM; JAK1: 29 nM; TYK2: 1253 nM
Relative Density:
1.36 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Abrocitinib can be used for drug development for immune-related diseases.
Library Information
Targets:
JAK
Receptors:
JAK; JAK1; JAK2
Pathways:
Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem cells
Plate Number:
AOCL-18
Plate Location:
e11
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
120 mg/mL; 371.05 mM
ALogP:
1.101
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
6
