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Vemurafenib
Cat. No.:
OB0125LY-072
Appearance:
Solid
Purity:
99.5%
Identity:
Confirmed by NMR and HPLC.
Size:
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Product Overview
Description:
Vemurafenib is a small molecule inhibitor targeting mutant BRAF kinase, which effectively inhibits the proliferation of tumor cells.
Synonym:
918504-65-1; PLX4032; Zelboraf; N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
CAS No.:
918504-65-1
Compound CID:
42611257
Formula:
C23H18ClF2N3O3S
Formula Weight:
489.92
Specification
Targets & IC50:
Ack1: 19 nM (cell free); B-Raf (V600E): 31 nM (cell free); SRMS: 18 nM (cell free); C-Raf1: 48 nM (cell free)
Relative Density:
1.46 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
Vemurafenib plays a key role in cancer and cell biology.
Library Information
Targets:
Src; Raf; MAPK; Autophagy; ACK
Receptors:
ACK1; Autophagy; B-Raf; B-Raf (V600E); C-Raf; FGR; MAP4K5 (KHS1); Raf; SRMS
Pathways:
Angiogenesis; Autophagy; Tyrosine kinase/adaptors; MAPK
Plate Number:
AOCL-7
Plate Location:
d4
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10 mM DMSO
DMSO Max Solubility:
18.33 mg/mL; 37.42 mM
Ethanol Max Solubility:
1 mg/mL
Saline Max Solubility:
9 mg/mL; 18.37 mM
ALogP:
4.953
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
7
