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Vemurafenib
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Cat. No.:
OB0125LY-072
Size:
10 mg; 50 mg; 100 mg; 200 mg; 500 mg
CAS No.:
918504-65-1
Compound CID:
42611257
Specification
Description:
Vemurafenib is a small molecule inhibitor targeting mutant BRAF kinase, which effectively inhibits the proliferation of tumor cells.
Formula Weight:
489.92
Stability:
3 years in powder form.
Applications:
Vemurafenib plays a key role in cancer and cell biology.
Storage:
Storage at -20°C.
Formula:
C23H18ClF2N3O3S
Appearance:
Solid
Purity:
99.5%
Identity:
Confirmed by NMR and HPLC.
Targets&IC50:
Ack1: 19 nM (cell free); B-Raf (V600E): 31 nM (cell free); SRMS: 18 nM (cell free); C-Raf1: 48 nM (cell free)
Relative Density:
1.46 g/cm3
Library Information
Plate Number:
AOCL-7
Plate Location:
d4
Empty Location:
a1-h1; a12-h12
Formulation:
10mM DMSO
Container:
96-well plate
Pathways:
Angiogenesis; Autophagy; Tyrosine kinase/adaptors; MAPK
Targets:
Src; Raf; MAPK; Autophagy; ACK
Receptors:
ACK1; Autophagy; B-Raf; B-Raf (V600E); C-Raf; FGR; MAP4K5 (KHS1); Raf; SRMS
DMSO Max Solubility (mg/mL):
18.33 mg/mL
DMSO Max Solubility (mM):
37.42 mM
Ethanol Max Solubility (mg/mL):
1 mg/mL
Saline Max Solubility (mg/mL):
9 mg/mL
Saline Max Solubility (mM):
18.37 mM
ALogP:
4.953
HBA_Count:
4
HBD_Count:
2
Rotatable Bond:
7