Bisindolylmaleimide I (GF109203X)

Cat. No.: OB0225WX-2674

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Bisindolylmaleimide I is a competitive PKC inhibitor (IC50: ~16-20 nM for alpha, beta, and gamma isoforms) that shows extreme selectivity (over 3000-fold) over EGFR and insulin receptors.

Synonym: GO 6850; 133052-90-1; GF109203X; GF 109203X; GF-109203X; Go 6850; Go-6850; 3-(1-(3-(Dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; 3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione; BIM-1; Bisindolylmaleimide I (GF 109203X); 2-[1-(3-dimethylaminopropyl)indol-3-yl]-3-(indol-3-yl)maleimide; 2-(1-(3-Dimethylaminopropyl)indol-3-yl)-3-(indol-3-yl)maleimide; 1H-Pyrrole-2,5-dione, 3-(1-(3-(dimethylamino)propyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-; 1H-Pyrrole-2,5-dione, 3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-; Bisindolylmaleimide I (GF109203X); 3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione; 3-[1-[3-(dimethylamino)propyl]-1h-indol-3-yl]-4-(1h-indol-3-yl)-1h-pyrrole-2,5-dione; BI1; MFCD00236428; Bisindolylmaleimide 1; 3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS No.: 133052-90-1

Compound CID: 2396

Formula: C₂₅H₂₄N₄O₂

Formula Weight: 412.48

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Bisindolylmaleimide I is used in cell signaling research as a potent and selective inhibitor of protein kinase C (PKC) to examine the contribution of PKC isoforms to various cellular physiological responses.