Go6976

Cat. No.: OB0225WX-2667

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Go6976 is a potent PKC inhibitor specifically targeting the alpha and beta-1 isoforms (IC50: 2.3 nM and 6.2 nM) and serves as an effective antagonist of JAK2 and Flt3.

Synonym: PD406976; 136194-77-9; Go 6976; GO6976; Go-6976; Goe 6976; 3-(13-Methyl-5-oxo-6,7-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12(13H)-yl)propanenitrile; 12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole; 12H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-; 12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile, 5,6,7,13-tetrahydro-13-methyl-5-oxo-; 12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrolo[3,4-c]carbazole; 3-(13-methyl-5-oxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)propanenitrile; 5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile; Goe-6976; 3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10.0^{4,9.0^{11,15.0^{17,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile; 3-(23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4,6,8,10,15,17,19,21-nonaen-3-yl)propanenitrile; 3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0(2),(1)?.0?,?.0(1)(1),(1)?.0(1)?,(2)(2)]tricosa-1(16),2(10),4(9),5,7,11(15),17(22),18,20-nonaen-3-yl}propanenitrile

CAS No.: 136194-77-9

Compound CID: 3501

Formula: C₂₄H₁₈N₄

Formula Weight: 377.42

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Go6976 is utilized in biochemical research as a potent inhibitor of conventional PKC isoforms and PKD to investigate the role of kinase-mediated signaling in cell cycle regulation and calcium-dependent processes.