(Z)-Guggulsterone

Cat. No.: OB0225WX-1662

Appearance: Solid

Purity: ≥99%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: (Z)-Guggulsterone acts as a plant-derived steroid that triggers apoptotic pathways in prostate cancer cells and disrupts angiogenesis by specifically inhibiting the VEGF–VEGF-R2–Akt signaling axis.

Synonym: Z-Guggulsterone; 39025-23-5; Guggulsterone; Guggulsterone E&Z; Guggulsterones Z; Cis-Guggulsterone; Guggulsterone, (Z)-; Z/E-Guggulsterone; (Z)-Pregna-4,17(20)-diene-3,16-dione; Pregna-4,17(20)-diene-3,16-dione; (8R,9S,10R,13S,14S,17Z)-17-ethylidene-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione; Pregna-4,17(20)-diene-3,16-dione, (17Z)-; (17Z)-Pregna-4,17(20)-diene-3,16-dione; Guggulsterone; Guglip; Gugulipid; (17Z)-Guggulsterone; Guggulsterones E&Z; 4,17(20)-cis-Pregnadiene-3,6-dione; GS; MFCD01310757; (1S,2R,10R,11S,14Z,15S)-14-ethylidene-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-5,13-dione; (1Z,3aS,3bR,9aR,9bS,11aS)-1-ethylidene-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-2,7-dione

CAS No.: 39025-23-5

Compound CID: 6450278

Formula: C₂₁H₂₈O₂

Formula Weight: 312.45

Specification

Relative Density: 1.10 g/cm³

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: (Z)-Guggulsterone is applied in metabolic studies as a farnesoid X receptor (FXR) antagonist to examine its impact on cholesterol homeostasis and bile acid metabolism.