Product Overview
Description:
AdipoUpX™ Human BBS1 MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the stable overexpression of the human BBS1 gene. BBS1 is a core component of the BBSome, critical for ciliary trafficking and hypothalamic leptin receptor signaling. The vector is optimized for hematopoietic stem cells, stem cells, embryonic types, etc., ensuring stable, high-level gene integration. This product accelerates progress in syndromic obesity research and is verified by comprehensive quality control screening against contaminants.
Production Cell Line:
HEK293T
Promoter:
Ubi; CMV; EF1a; Others
Product Availability:
Produced Upon Order
Specification
Titer Test:
qPCR
Insert Verification:
Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.
Sterility Test:
No microbial contamination was detected in any product.
Mycoplasma Test:
No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.
Other QC:
Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.
Storage:
The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.
Stability:
Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.
Shipping Condition:
Our MSCV retroviral products are shipped using dry ice.
Handling Notes:
Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.
Intended Use:
This product is intended for research use only and is not for use in diagnosis or therapeutic applications.
Product Disclaimer:
Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.
Target Profile
Gene Name:
BBS1
Full Name:
Bardet-Biedl syndrome 1
Gene Symbol:
BBS2L2
Summary:
BBS1 mutations are linked to type 1 Bardet-Biedl syndrome. The encoded protein is involved in the development of eyes, limbs, the heart, and the reproductive system. Disruption of BBS1 function contributes to the multisystemic manifestations of Bardet-Biedl syndrome, including obesity, retinal dystrophy, and polydactyly.
