AdipoUpX™ Human BBS2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human BBS2 MSCV Particle (Overexpression) is a powerful gene delivery tool designed for the long-term stable overexpression of the human BBS2 gene. As a member of the BBSome, BBS2 is essential for ciliary-mediated nutrient sensing. Its MSCV backbone is tailored for optimal performance in hematopoietic stem cells, stem cells, etc., facilitating the study of Bardet-Biedl syndrome-related obesity. This product allows for rapid validation of BBS2 function and is backed by comprehensive quality control to ensure data integrity and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: BBS2

Full Name: Bardet-Biedl syndrome 2

Gene Symbol: BBS; RP74

Gene ID: 583

RefSeq ID-1: NP_001364385.1

RefSeq ID-2: NM_001377456.1

Summary: BBS2 is a member of the Bardet-Biedl syndrome (BBS) gene family, which is associated with an autosomal recessive disorder characterized by obesity, pigmentary retinopathy, polydactyly, renal anomalies, and cognitive impairment. BBS proteins are structurally diverse but share roles in cilia formation and function. Many localize to basal bodies, ciliary axonemes, and pericentriolar regions, and participate in intracellular trafficking via microtubule-related transport. BBS2 forms part of the multiprotein BBSome complex with seven other BBS proteins.

AdipoUpX™ Human BBS2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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