AdipoUpX™ Human NTRK2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human NTRK2 MSCV Particle (Overexpression) is a stable integration tool for the specific and efficient overexpression of the human NTRK2 (TrkB) gene. This receptor is the primary gateway for BDNF signaling in the regulation of appetite and energy balance. This stable system is optimized for hematopoietic stem cells, stem cells, and other mammalian lineages, providing a robust tool for neurotrophic signaling research. The product is ready-to-use, and all viral systems undergo rigorous testing—including titer and mycoplasma detection—to ensure high performance and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: NTRK2

Full Name: Neurotrophic receptor tyrosine kinase 2

Gene Symbol: OBHD; TRKB; DEE58; trk-B; EIEE58; GP145-TrkB

Gene ID: 4915

RefSeq ID-1: NP_001007098.1

RefSeq ID-2: NM_001007097.3

Summary: NTRK2 encodes a membrane-spanning receptor tyrosine kinase that mediates neurotrophin-dependent signaling in the nervous system. Upon ligand engagement, the receptor undergoes autophosphorylation and activates downstream signaling cascades, including MAPK pathways, which promote neuronal differentiation and survival. Genetic alterations in NTRK2 have been associated with disturbances in energy balance, obesity, and mood-related disorders. The gene produces multiple transcript variants as a result of alternative splicing.

AdipoUpX™ Human NTRK2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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