AdipoUpX™ Human NCOA1 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human NCOA1 MSCV Particle (Overexpression) enables stable overexpression of the human NCOA1 gene, a nuclear receptor coactivator regulating transcriptional programs involved in lipid metabolism and energy balance. NCOA1 influences hormone-responsive pathways relevant to obesity research. The MSCV system supports high-level expression in stem cells and other mammalian cell lines. Comprehensive QC screening ensures experimental reliability.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: NCOA1

Full Name: Nuclear receptor coactivator 1

Gene Symbol: SRC1; KAT13A; RIP160; F-SRC-1; bHLHe42; bHLHe74

Gene ID: 8648

RefSeq ID-1: NP_001349879.1

RefSeq ID-2: NM_001362950.1

Summary: NCOA1 acts as a transcriptional coactivator for nuclear hormone receptors, including those for steroids. As a member of the p160 family, it possesses histone acetyltransferase activity, which opens up chromatin to allow gene expression. It directly binds nuclear receptors to boost their activity in a hormone-dependent manner, making it a central player in hormonal signaling.

AdipoUpX™ Human NCOA1 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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