AdipoUpX™ Human NR0B2 MSCV Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human NR0B2 MSCV Particle (Overexpression) is a professionally engineered vector particle providing efficient and stable overexpression of human NR0B2 (SHP). SHP acts as a critical nuclear receptor corepressor regulating bile acid and lipid metabolism. The vector is optimized for hematopoietic stem cells, stem cells, etc., facilitating the investigation of transcriptional repression in metabolic disorders. Clients can freely choose reporter genes through our flexible platform, while comprehensive quality control ensures the safety and efficacy of the viral products.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: Final QC confirmed the correct molecular size and integrity of the insert through specific PCR amplification.

Sterility Test: No microbial contamination was detected in any product.

Mycoplasma Test: No mycoplasma presence was detected in this final viral preparation upon comprehensive testing.

Other QC: Our service scope includes both customized supplementary testing and comprehensive in vitro/in vivo transduction assessments.

Storage: The necessity of immediate transfer to -80 °C storage following receipt is crucial for upholding the product's integrity.

Stability: Biological activity remains intact for 6-12 months when stored at -80°C. Once removed from the freezer, the diluted working material is stable for up to 2-3 weeks at 4°C.

Shipping Condition: Our MSCV retroviral products are shipped using dry ice.

Handling Notes: Store the vector according to specified conditions and aliquot it immediately upon receipt into low-protein-binding tubes, which is necessary to maintain titer because viral particles are highly sensitive to both temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Throughout all operational processes, users bear ultimate responsibility for product storage, handling, and compliance with all safety protocols, laws, regulations, and biosafety requirements. Although our company commits to product quality via rigorous internal QC inspections, the complexity of experimental conditions means we cannot guarantee product performance or experimental results in any specific application.

Target Profile

Gene Name: NR0B2

Full Name: Nuclear receptor subfamily 0 group B member 2

Gene Symbol: SHP; SHP1

Gene ID: 8431

RefSeq ID-1: NP_068804.1

RefSeq ID-2: NM_021969.3

Summary: NR0B2 encodes an atypical orphan nuclear receptor that contains a putative ligand-binding domain but lacks a standard DNA-binding domain. It interacts with retinoid, thyroid, and estrogen receptors, repressing their ligand-dependent transcriptional activity. The protein exerts repression through two mechanisms: competing with coactivators and direct transcriptional inhibition. NR0B2 functions as a transcriptional modulator within the nuclear hormone receptor family, influencing diverse cellular responses even in the absence of known ligands.

AdipoUpX™ Human NR0B2 MSCV Particle (Overexpression)

Product Overview

Specification

Target Profile

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