Sirtinol

Cat. No.: OB0225WX-2521

Appearance: Solid

Purity: ≥97%

Identity: Confirmed by NMR, and HPLC.

Size:

INQUIRY Datasheet MSDS

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Product Overview

Description: Sirtinol acts as a specific dual antagonist of SIRT1 and SIRT2, with measured IC50 values of 131 micromolar and 38 micromolar in biochemical assays, respectively.

Synonym: 410536-97-9; 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide; 2-[(2-hydroxynaphthalen-1-yl)methylideneamino]-N-(1-phenylethyl)benzamide; 2-{[(2-hydroxy-1-naphthyl)methylene]amino}-N-(1-phenylethyl)benzamide; Sir Two Inhibitor Naphthol; (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide; 2-(((2-Hydroxynaphthalen-1-yl)methylene)amino)-N-(1-phenylethyl)benzamide; 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide; 2-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]- N -(1-phenylethyl)benzamide; 2-(((2-hydroxy-1-naphthyl)methylene)amino)-N-(1-phenylethyl)benzamide; MFCD00810186; 2-[(2-hydroxynaphthalen-1-yl-methylene)amino]-n-(1-phenethyl)benzamide; 2-[(2-oxo-1-naphthalenylidene)methylamino]-N-(1-phenylethyl)benzamide; 2-(((2-Oxonaphthalen-1(2H)-ylidene)methyl)amino)-N-(1-phenylethyl)benzamide; 2-[(2-hydroxy-naphthalen-1-ylmethylene)-amino]-N-(1-phenyl-ethyl)-benzamide; 2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide; 2-{[(E)-(2-hydroxynaphthalen-1-yl)methylidene]amino}-N-(1-phenylethyl)benzamide; 2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide

CAS No.: 410536-97-9

Compound CID: 2827646

Formula: C₂₆H₂₂N₂O₂

Formula Weight: 394.47

Specification

Stability: 3 years in powder form.

Storage: Storage at -20°C.

Applications: Sirtinol is utilized in epigenetic research as a selective inhibitor of SIRT1 and SIRT2 to investigate the role of sirtuin-mediated deacetylation in regulating cell longevity and stress resistance.