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SirReal2
Cat. No.:
OB0225WX-2708
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
SirReal2 is a highly specific small molecule inhibitor of Sirt2, featuring a half-maximal inhibitory concentration (IC50) of 140 nM.
Synonym:
709002-46-0; SirReal 2; 2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide; 2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide; 2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide; SirReal-2; 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[5-(naphthalen-1-ylmethyl)-1,3-thiazol-2-yl]acetamide; 2-(4,6-dimethylpyrimidin-2-ylthio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide
CAS No.:
709002-46-0
Compound CID:
1096292
Formula:
C22H20N4OS2
Formula Weight:
420.55
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SirReal2 is used in epigenetic research as a highly selective SIRT2 inhibitor to investigate the molecular basis of sirtuin-mediated deacetylation and the regulation of specific protein targets like alpha-tubulin.
Library Information
Target:
Sirtuin
Receptor:
SIRT2
Pathways:
Epigenetics
Plate Number:
L6700-09
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
84 mg/mL; 199.74 mM
ALogP:
4.065
HBA_Count:
4
HBD_Count:
1
Rotatable Bond:
6
