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AK 7
Cat. No.:
OB0225WX-2648
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
AK 7 is a brain-penetrant small molecule that selectively inhibits SIRT2 with a half-maximal inhibitory concentration (IC50) of 15.5 microM.
Synonym:
420831-40-9; AK-7; 3-(azepan-1-ylsulfonyl)-N-(3-bromophenyl)benzamide; AK 7; 3-(azepane-1-sulfonyl)-N-(3-bromophenyl)benzamide; Benzamide, N-(3-bromophenyl)-3-((hexahydro-1H-azepin-1-yl)sulfonyl)-; 3-(1-azepanylsulfonyl)-N-(3-bromophenyl)benzamide; 3-(1-Azepanylsulfonyl)-N-(3-bromphenyl)benzamide; 3-(1-azepanylsulfonyl-)-N-(3-bromophenyl)benzamide
CAS No.:
420831-40-9
Compound CID:
1328033
Formula:
C19H21BrN2O3S
Formula Weight:
437.35
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
AK 7 is used in neurobiology research as a selective inhibitor of Sirtuin 2 (SIRT2) to investigate the role of tubulin deacetylation in neurodegenerative models and cellular stress responses.
Library Information
Target:
Sirtuin
Receptor:
SIRT2
Pathways:
Epigenetics
Plate Number:
L6700-07
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
87 mg/mL; 198.93 mM
Ethanol Max Solubility:
3 mg/mL
ALogP:
3.853
HBA_Count:
3
HBD_Count:
1
Rotatable Bond:
4
