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ML264
Cat. No.:
0225LY-0759
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
ML264 is a selective inhibitor of Kruppel-like factor 5 (KLF5) that demonstrates potent growth inhibition against colorectal cancer.
Synonym:
1550008-55-3; (E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide; 2-Propenamide, 3-(3-chlorophenyl)-N-[2-[methyl(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)amino]-2-oxoethyl]-, (2E)-; (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamide
CAS No.:
1550008-55-3
Compound CID:
51003603
Formula:
C17H21ClN2O4S
Formula Weight:
384.88
Specification
Targets&IC50:
KLF5: 29 nM
Relative Density:
1.35 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ML264 can be used in cancer biology to investigate the inhibition of the transcription factor KLF5 and its role in colorectal cancer cell growth.
Library Information
Target:
DNA/RNA synthesis; KLF
Receptor:
KLF5
Pathways:
Cell cycle/Checkpoint; DNA damage/DNA repair; MAPK
Plate Number:
AOCL-10
Plate Location:
g6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
100 mg/mL; 259.82 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
