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ABC1183
Cat. No.:
0225LY-1272
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
ABC1183 is an orally active diaminothiazole that halts the growth of multiple cancer cell lines by inducing G2/M arrest and modulating the phosphorylation of β-catenin and glycogen synthetase.
Synonym:
ABC 1183; ABC-1183; 1042735-18-1; 1042735-18-1; Benzonitrile, 4-[[4-amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]-; 4-[4-Amino-2-(4-methylanilino)-1,3-thiazole-5-carbonyl]benzonitrile; 4-(4-Amino-2-(p-tolylamino)thiazole-5-carbonyl)benzonitrile; 4-(4-Amino-2-p-tolylamino-thiazole-5-carbonyl)-benzonitrile; 4-[[4-Amino-2-[(4-methylphenyl)amino]-5-thiazolyl]carbonyl]benzonitrile
CAS No.:
1042735-18-1
Compound CID:
134500787
Formula:
C18H14N4OS
Formula Weight:
334.39
Specification
Targets&IC50:
GSK-3α: 327 nM; GSK-3β: 657 nM; CDK9-CyclinT1: 321 nM
Relative Density:
1.38 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
ABC1183 can be used in inflammatory research to study the dual inhibition of PLK1 and GSK-3.
Library Information
Target:
GSK-3; CDK
Receptor:
GSK-3α; GSK-3β; CDK9/cyclin T1
Pathways:
Wnt/β-Catenin signaling; Cell cycle; Transcription regulation; Stem cell regulation
Plate Number:
AOCL-17
Plate Location:
c9
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
3.35 mg/mL; 10.02 mM
