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SL327
Cat. No.:
0225LY-1460
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
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Product Overview
Description:
SL327 is a selective MEK1/2 inhibitor (IC50: 0.18 μM/0.22 μM) characterized by its ability to effectively cross the blood-brain barrier.
Synonym:
SL 327; SL-327; 305350-87-2; MEK1/2 Inhibitor; (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile; (Z)-3-Amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile; Benzeneacetonitrile, alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-; (E)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile; alpha-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile; 3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile; (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile; (Z)-3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile; 3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]acrylonitrile; 3-amino-3-[(4-aminophenyl)thio]-2-[2-(trifluoromethyl)phenyl]-2-propenenitrile
CAS No.:
305350-87-2
Compound CID:
9549284
Formula:
C16H12F3N3S
Formula Weight:
335.35
Specification
Targets&IC50:
MEK2: 0.22 μM; MEK1: 0.18 μM
Relative Density:
1.40 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
SL327 can be used in signaling research to explore the inhibition of MEK1/2 and its impact on extracellular signal-regulated kinase (ERK) activation.
Library Information
Target:
DNA/RNA synthesis; MEK
Receptor:
AP-1; MEK1; MEK2
Pathways:
Cell cycle/Checkpoint; MAPK; DNA damage/DNA repair
Plate Number:
AOCL-19
Plate Location:
g3
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
50 mg/mL; 149.1 mM
Ethanol Max Solubility:
16.8 mg/mL; 50.1 mM
