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DIF-3
Cat. No.:
0225LY-1263
Appearance:
Solid
Purity:
≥98%
Identity:
Confirmed by NMR, and HPLC.
Size:
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Product Overview
Description:
DIF-3 suppresses the growth of HeLa cervical cancer cells by triggering the degradation of cyclin D1 and c-Myc through GSK-3β activation, while also hindering the Wnt/β-catenin signaling pathway.
Synonym:
113411-17-9; 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone; Dif-3 (dictyostelium); 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one; Differentiation-inducing factor 3; Differentiation-inducing factor-3, Dictyostelium; 1-Hexanone, 1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)-
CAS No.:
113411-17-9
Compound CID:
3081033
Formula:
C13H17ClO4
Formula Weight:
272.72
Specification
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
DIF-3 can be used in developmental biology and cancer research to study its role in cell differentiation and anti-tumor activity.
Library Information
Target:
GSK-3; Wnt/beta-catenin; CDK
Receptor:
GSK-3β; Wnt/β-Catenin; Cyclin D1
Pathways:
Cell cycle/Checkpoint; Stem cell regulation; Cytoskeletal signaling; PI3K/Akt/mTOR signaling
Plate Number:
AOCL-17
Plate Location:
b10
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
90 mg/mL; 330.01 mM
