Products
Online Inquiry
CKI-7
Cat. No.:
0225LY-0806
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
CKI-7 is a selective Cdc7 kinase inhibitor and a potent, ATP-competitive inhibitor of Casein kinase 1 (CK1) with an IC50 of 6 uM; it also demonstrates inhibitory effects on MSK1, ribosomal S6 kinase-1 (S6K1), and SGK.
Synonym:
1177141-67-1; CKI-7 dihydrochloride; N-(2-Aminoethyl)-5-chloro-8-isoquinolinesulfonamide dihydrochloride; N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulphonamide dihydrochloride
CAS No.:
1177141-67-1
Compound CID:
16078955
Formula:
C11H14Cl3N3O2S
Formula Weight:
358.67
Specification
Targets&IC50:
CK1: 6 μM(IC50); CK1: 8.5 μM(Ki)
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
CKI-7 can be used in biochemical assays to investigate the selective inhibition of casein kinase 1 (CK1).
Library Information
Target:
ROCK; SGK; Casein kinase; CDK; S6 Kinase
Receptor:
Cdc7; CK1; MSK1; S6K1; SGK
Pathways:
Cell cycle/Checkpoint; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Cytoskeletal signaling; Stem cell regulation
Plate Number:
AOCL-11
Plate Location:
d5
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
65 mg/mL; 181.23 mM
