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PHA-767491
Cat. No.:
0225LY-1279
Appearance:
Solid
Purity:
≥99%
Identity:
Confirmed by NMR, and LC-MS.
Size:
Add to basket
Product Overview
Description:
PHA-767491 is an ATP-competitive dual inhibitor targeting Cdc7 and CDK9 with IC50 values of 10 nM and 34 nM, respectively.
Synonym:
CAY10572; PHA767491; PHA 767491; 845714-00-3; 2-pyridin-4-yl-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one; 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one; 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one; 2-(pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one; 2-Pyridin-4-yl-1,5,6,7-tetrahydropyrrolo(3,2-C)pyridin-4-one; 1,5,6,7-Tetrahydro-2-(4-pyridinyl)-4H-pyrrolo(3,2-C)pyridin-4-one; 2-Pyridin-4-yl-1,5,6,7-tetrahydro-pyrrolo(3,2-C)pyridin-4-one; 2-(Pyridin-4-Yl)-1,5,6,7-Tetrahydro-4h-Pyrrolo[3,2-C]pyridin-4-One; 4H-Pyrrolo(3,2-C)pyridin-4-one, 1,5,6,7-tetrahydro-2-(4-pyridinyl)-
CAS No.:
845714-00-3
Compound CID:
11715767
Formula:
C12H11N3
Formula Weight:
213.24
Specification
Targets&IC50:
CDK9: 34 nM; CDC7: 10 nM
Relative Density:
1.287 g/cm3
Stability:
3 years in powder form.
Storage:
Storage at -20°C.
Applications:
PHA-767491 can be used in biochemical research to investigate the suppression of DNA origin firing through Cdc7 inhibition.
Library Information
Target:
GSK-3; CDK; Cholecystokinin
Receptor:
Cdc7; CDK1; CDK2; CDK9; GSK-3β
Pathways:
Cell cycle/Checkpoint; GPCR/G protein signaling; PI3K/Akt/mTOR signaling; Stem cell regulation
Plate Number:
AOCL-17
Plate Location:
d6
Empty Location:
a1-h1; a12-h12
Container:
96-well plate
Formulation:
10mM DMSO
DMSO Max Solubility:
40 mg/mL; 187.58 mM
Water Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
Ethanol Max Solubility:
<1 mg/mL (insoluble or slightly soluble)
