AdipoUpX™ Human MC4R Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human MC4R Lentiviral Particle (Overexpression) is a professionally engineered vector particle providing efficient and long-lasting overexpression of human MC4R. As MC4R is a central GPCR in the hypothalamic appetite pathway, this stable integration system is an ideal tool for drug screening and neuroendocrinology research. It facilitates investigation of downstream signaling mechanisms and α-MSH receptor activation. All viral particle products undergo comprehensive quality control to ensure safety and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: MC4R

Full Name: Melanocortin receptor 4

Gene Symbol: BMIQ20

Gene ID: 4160

RefSeq ID: NM_005912.3, NP_005903.2

Summary: The protein encoded by the MC4R gene is a G protein-coupled receptor (GPCR) located on the cell membrane, serving as a core component of the central appetite regulation circuit. It plays a crucial role in balancing energy intake by mediating interactions with ligands such as adrenocorticotropic hormone (ACTH) and melanocyte-stimulating hormone (MSH). Functional defects in MC4R constitute the most common monogenic cause of obesity, leading to autosomal dominant obesity. This gene lacks introns, underscoring its direct and critical role in neuroendocrine signaling.

AdipoUpX™ Human MC4R Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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