AdipoUpX™ Human LEP Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human LEP Lentiviral Particle (Overexpression) is a ready-to-use, high-titer vector particle. It is professionally engineered for the specific, efficient, and long-lasting stable overexpression of the human LEP gene. The lentivirus characteristics ensure the target gene integrates into the host cell genome, establishing reliable, stable cell lines. This makes it suitable for in-depth research in obesity, endocrinology, and energy homeostasis. Our vector system features a modular design, offering high flexibility for customization. Comprehensive quality control is performed to ensure both product safety and efficacy.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: LEP

Full Name: Leptin

Gene Symbol: OBS; OB; LEPD

Gene ID: 3952

RefSeq ID: NM_000230.3, NP_000221.1

Summary: LEP (leptin) protein is a key signaling molecule secreted by adipocytes, primarily functioning as a thermostat for body weight to regulate systemic energy balance. By binding to specific receptors in the brain, circulating leptin activates signaling pathways that effectively suppress appetite and accelerate metabolism. Beyond its classic metabolic role, LEP exerts broad endocrine regulatory effects, influencing immune function, inflammation, angiogenesis, and reproductive processes. Clinical mutations in LEP and its regulatory regions are directly associated with the onset and progression of severe obesity, hypogonadism, and type 2 diabetes.

AdipoUpX™ Human LEP Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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