AdipoUpX™ Human CRP Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human CRP Lentiviral Particle (Overexpression) is professionally engineered for the efficient and long-lasting overexpression of the human CRP gene. As a classic marker of systemic inflammation, its stable expression in cell models facilitates investigation into the cross-talk between the liver and adipose tissue in obesity. Every batch of this high-titer product undergoes rigorous internal quality control validation. Our modular vector design offers high flexibility for the customization of promoters and labels for precise targeted delivery.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: CRP

Full Name: C-reactive protein

Gene Symbol: PTX1

Gene ID: 1401

RefSeq ID-1: NP_000558.2

RefSeq ID-2: NM_000567.3

Summary: CRP encodes a pentraxin family protein involved in complement activation and regulation through interactions with pattern recognition molecules and complement regulators. The protein contains a calcium-dependent ligand-binding domain with a flattened beta-jellyroll structure and exists as a pentamer in circulation or a monomer in tissues. CRP contributes to host defense by recognizing pathogens and damaged cells and initiating their clearance via humoral and cellular mechanisms. Plasma CRP levels increase dramatically during acute-phase responses to infection, tissue injury, or inflammation. Chronic elevation of CRP has been linked to adult-onset obesity.

AdipoUpX™ Human CRP Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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