AdipoUpX™ Human INSR Lentiviral Particle (Overexpression)

Product Overview

Description: AdipoUpX™ Human INSR Lentiviral Particle (Overexpression) is a powerful gene delivery tool specifically designed for the stable overexpression of the human INSR (Insulin Receptor) gene. This system is a reliable asset for researching insulin sensitivity and the molecular triggers of receptor resistance. Genome integration enables the establishment of stable cell lines for high-throughput signaling screening. All particles undergo rigorous quality control screening, and our customizable platform allows clients to freely select key functional components to meet specific research needs.

Production Cell Line: HEK293T

Promoter: Ubi; CMV; EF1a; Others

Product Availability: Produced Upon Order

Specification

Titer Test: qPCR

Insert Verification: PCR analysis was performed to verify the complete genomic sequence of all viral vector preparations.

Sterility Test: This product was certified sterile following successful microbial growth analysis.

Mycoplasma Test: The production quality control confirmed the absence of any mycoplasmal agents.

Other QC: This comprehensive process includes customized supplementary testing alongside in vitro and in vivo transduction assessments to elucidate transgene expression and functionality.

Storage: To maintain product integrity, immediate transfer of the vector to a -80 °C is essential following its receipt.

Stability: Continuous storage at -80°C ensures excellent long-term stability for 6-12 months. Once thawed, the product's working solution should be refrigerated at 4°C and used within 2-3 weeks.

Shipping Condition: Our lentivirus viral products are shipped using dry ice.

Handling Notes: Ensure all operations are performed within a biosafety cabinet; upon receiving the vector, immediately aliquot it into low-protein-binding tubes and store according to specified conditions, thus avoiding the titer loss caused by sensitivity to temperature fluctuations and freeze-thaw cycles.

Intended Use: This product is intended for research use only and is not for use in diagnosis or therapeutic applications.

Product Disclaimer: Given the diversity and complexity of experimental conditions, we do not guarantee product performance or experimental results in any specific application, despite our company's commitment to product quality and the rigorous internal QC inspections all products have undergone. Ultimate responsibility remains with the user for all operational processes, including storage, handling, and compliance with safety and biosafety protocols.

Target Profile

Gene Name: INSR

Full Name: Insulin receptor

Gene Symbol: HHF5; CD220

Gene ID: 3643

RefSeq ID-1: NP_000199.2

RefSeq ID-2: NM_000208.4

Summary: INSR encodes a receptor tyrosine kinase that forms a heterotetrameric receptor composed of alpha and beta subunits following proteolytic processing. The binding of insulin or other ligands activates the insulin signaling pathway, regulating glucose uptake, carbohydrate, lipid, and protein metabolism. Mutations in INSR result in severe inherited insulin resistance syndromes, including type A insulin resistance, Donohue syndrome, and Rabson-Mendenhall syndrome. Alternative splicing produces multiple transcript variants.

AdipoUpX™ Human INSR Lentiviral Particle (Overexpression)

Product Overview

Specification

Target Profile

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